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dc.contributor.authorVoomolen, DC
dc.contributor.authorHaagsma, JA
dc.contributor.authorPolinder, Suzanne
dc.contributor.authorMaas, AIR
dc.contributor.authorSteyerberg, Ewout W
dc.contributor.authorVulekovic, Peter
dc.contributor.authorSewalt, CA
dc.contributor.authorGravesteijn, BY
dc.contributor.authorCovic, Amra
dc.contributor.authorAndelic, Nada
dc.contributor.authorPlass, AM
dc.contributor.authorvon Steinbüchel, Nicole
dc.contributor.authorVik, Anne
dc.contributor.authorAndreassen, Lasse
dc.contributor.authorAnke, Audny
dc.contributor.authorFrisvold, Shirin Kordasti
dc.contributor.authorHelseth, Eirik
dc.contributor.authorSkandsen, Toril
dc.contributor.authorRøise, Olav
dc.contributor.authorHåberg, Asta
dc.contributor.authorRøe, Cecilie
dc.date.accessioned2020-03-04T13:35:51Z
dc.date.available2020-03-04T13:35:51Z
dc.date.issued2019-11-08
dc.description.abstractAbstract The aim of this study was to assess the occurrence of post-concussion symptoms and post-concussion syndrome (PCS) in a large cohort of patients after complicated and uncomplicated mild traumatic brain injury (mTBI) at three and six months post-injury. Patients were included through the prospective cohort study: Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI). Patients enrolled with mTBI (Glasgow Coma Scale 13-15) were further differentiated into complicated and uncomplicated mTBI based on the presence or absence of computed tomography abnormalities, respectively. The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) assessed post-concussion symptoms and PCS according to the mapped ICD-10 classification method. The occurrence of post-concussion symptoms and syndrome at both time points was calculated. Chi square tests were used to test for differences between and within groups. Logistic regression was performed to analyse the association between complicated versus uncomplicated mTBI and the prevalence of PCS. Patients after complicated mTBI reported slightly more post-concussion symptoms compared to those after uncomplicated mTBI. A higher percentage of patients after complicated mTBI were classified as having PCS at three (complicated: 46% vs. uncomplicated: 35%) and six months (complicated: 43% vs. uncomplicated 34%). After adjusting for baseline covariates, the effect of complicated versus uncomplicated mTBI at three months appeared minimal: odds ratio 1.25 (95% confidence interval: 0.95-1.66). Although patients after complicated mTBI report slightly more post-concussion symptoms and show higher PCS rates compared to those after uncomplicated mTBI at three and six months, complicated mTBI was only found a weak indicator for these problems. KEYWORDS: complicated mild traumatic brain injury; post-concussion symptoms; post-concussion syndrome; traumatic brain injuryen_US
dc.identifier.citationVoomolen, Haagsma, Polinder S, Maas, Steyerberg EW, Vulekovic P, Sewalt, Gravesteijn, Covic, Andelic N, Plass, von Steinbüchel N, Vik A, Andreassen L, Anke A, Frisvold SK, Helseth E, Skandsen T, Røise O, Håberg A, Røe C. Post-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Study. Journal of Clinical Medicine. 2019en_US
dc.identifier.cristinIDFRIDAID 1759506
dc.identifier.doi10.3390/jcm8111921
dc.identifier.issn2077-0383
dc.identifier.urihttps://hdl.handle.net/10037/17612
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalJournal of Clinical Medicine
dc.relation.projectIDEU: 602150en_US
dc.relation.projectIDNorges forskningsråd: 272789en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EU/FP7-HEALTH/602150/?/Collaborative European NeuroTrauma Effectiveness Research in TBI/CENTER-TBI/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HELSEVEL-H/272789/Norway/Research Centre for Habilitation and Rehabilitation Models and Services/CHARM 2/en_US
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/31717436
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titlePost-Concussion Symptoms in Complicated vs. Uncomplicated Mild Traumatic Brain Injury Patients at Three and Six Months Post-Injury: Results from the CENTER-TBI Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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