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dc.contributor.authorRussell, Ashley E.
dc.contributor.authorSneider, Alexandra
dc.contributor.authorWitwer, Kenneth W.
dc.contributor.authorBergese, Paolo
dc.contributor.authorBhattacharyya, Suvendra N.
dc.contributor.authorCocks, Alexander
dc.contributor.authorCocucci, Emanuele
dc.contributor.authorErdbrügger, Uta
dc.contributor.authorFalcón-Pérez, Juan M.
dc.contributor.authorFreeman, David W.
dc.contributor.authorGallagher, Thomas M.
dc.contributor.authorHu, Shuaishuai
dc.contributor.authorHuang, Yiyao
dc.contributor.authorJay, Steven M.
dc.contributor.authorKano, Shin-ichi
dc.contributor.authorLavieu, Gregory
dc.contributor.authorLeszczynska, Aleksandra
dc.contributor.authorLlorente Martinez, Alicia
dc.contributor.authorLu, Quan
dc.contributor.authorMahairaki, Vasiliki
dc.contributor.authorMuth, Dillon C.
dc.contributor.authorHooten, Nicole Noren
dc.contributor.authorOstrowski, Matias
dc.contributor.authorPrada, Ilaria
dc.contributor.authorSahoo, Susmita
dc.contributor.authorSchøyen, Tine Hiorth
dc.contributor.authorSheng, Lifu
dc.contributor.authorTesch, Deanna
dc.contributor.authorVan Niel, Guillaume
dc.contributor.authorVandenbroucke, Roosmarijn E.
dc.contributor.authorVerweij, Frederik J.
dc.contributor.authorVillar, Ana V.
dc.contributor.authorWauben, Marca
dc.contributor.authorWehman, Ann M.
dc.contributor.authorYin, Hang
dc.contributor.authorCarter, David Raul Francisco
dc.contributor.authorVader, Pieter
dc.date.accessioned2020-03-04T13:40:11Z
dc.date.available2020-03-04T13:40:11Z
dc.date.issued2019-11-08
dc.description.abstractParacrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer membranes. To evaluate research progress on membranes and EVs, the International Society for Extracellular Vesicles (ISEV) conducted a workshop in March 2018 in Baltimore, Maryland, USA, bringing together key opinion leaders and hands-on researchers who were selected on the basis of submitted applications. The workshop was accompanied by two scientific surveys and covered four broad topics: EV biogenesis and release; EV uptake and fusion; technologies and strategies used to study EV membranes; and EV transfer and functional assays. In this ISEV position paper, we synthesize the results of the workshop and the related surveys to outline important outstanding questions about EV membranes and describe areas of consensus. The workshop discussions and survey responses reveal that while much progress has been made in the field, there are still several concepts that divide opinion. Good consensus exists in some areas, including particular aspects of EV biogenesis, uptake and downstream signalling. Areas with little to no consensus include EV storage and stability, as well as whether and how EVs fuse with target cells. Further research is needed in these key areas, as a better understanding of membrane biology will contribute substantially towards advancing the field of extracellular vesicles.en_US
dc.identifier.citationRussell, Sneider, Witwer KW, Bergese P, Bhattacharyya, Cocks, Cocucci E, Erdbrügger, Falcón-Pérez JM, Freeman, Gallagher, Hu, Huang Y, Jay, Kano S, Lavieu G, Leszczynska A, Llorente Martinez A, Lu Q, Mahairaki, Muth, Hooten, Ostrowski M, Prada I, Sahoo S, Schøyen TH, Sheng, Tesch, Van Niel G, Vandenbroucke, Verweij, Villar, Wauben M, Wehman, Yin H, Carter, Vader P. Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. Journal of Extracellular Vesicles. 2019;8(1):1-35en_US
dc.identifier.cristinIDFRIDAID 1757990
dc.identifier.doi10.1080/20013078.2019.1684862
dc.identifier.issn2001-3078
dc.identifier.urihttps://hdl.handle.net/10037/17613
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalJournal of Extracellular Vesicles
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleBiological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshopen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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