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dc.contributor.authorDjordjilovic, Vera
dc.contributor.authorPage, Christian Magnus
dc.contributor.authorGran, Jon Michael
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorVeierød, Marit Bragelien
dc.contributor.authorThoresen, Magne
dc.date.accessioned2020-03-19T14:47:07Z
dc.date.available2020-03-19T14:47:07Z
dc.date.issued2019-05-09
dc.description.abstractWe address the problem of testing whether a possibly high‐dimensional vector may act as a mediator between some exposure variable and the outcome of interest. We propose a global test for mediation, which combines a global test with the intersection‐union principle. We discuss theoretical properties of our approach and conduct simulation studies that demonstrate that it performs equally well or better than its competitor. We also propose a multiple testing procedure, ScreenMin, that provides asymptotic control of either familywise error rate or false discovery rate when multiple groups of potential mediators are tested simultaneously. We apply our approach to data from a large Norwegian cohort study, where we look at the hypothesis that smoking increases the risk of lung cancer by modifying the level of DNA methylation.en_US
dc.descriptionThis is the peer reviewed version of the following article: Djordjilovic, V., Page, C.M., Gran, J.M., Nøst, T.H., Sandanger, T.M., Veierød, M.B. & Thoresen, M. (2019). Global test for high‐dimensional mediation: Testing groups of potential mediators. <i>Statistics in Medicine, 38</i>(18), 3346-3360, which has been published in final form at <a href=https://doi.org/10.1002/sim.8199>https://doi.org/10.1002/sim.8199. </a>This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationDjordjilovic V, Page CM, Gran JM, Nøst TH, Sandanger TM, Veierød MB, Thoresen M. Global test for high-dimensional mediation: Testing groups of potential mediators. Statistics in Medicine. 2019;38:3346-3360en_US
dc.identifier.cristinIDFRIDAID 1708652
dc.identifier.doi10.1002/sim.8199
dc.identifier.issn0277-6715
dc.identifier.issn1097-0258
dc.identifier.urihttps://hdl.handle.net/10037/17814
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalStatistics in Medicine
dc.relation.projectIDNorges forskningsråd: 248804en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/248804/Norway/National training initiative to make better use of biobanks and health registry data//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 John Wiley & Sons, Ltd.en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleGlobal test for high-dimensional mediation: Testing groups of potential mediatorsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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