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dc.contributor.authorBjerkli, Inger-Heidi
dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.contributor.authorNginamau, Elisabeth Sivy
dc.contributor.authorLaurvik, Helene
dc.contributor.authorSøland, Tine Merete
dc.contributor.authorCostea, Daniela Elena
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorSteigen, Sonja Eriksson
dc.date.accessioned2020-08-04T08:41:51Z
dc.date.available2020-08-04T08:41:51Z
dc.date.issued2020-06-30
dc.description.abstractWe wanted to evaluate the prognostic value of common histopathological variables in a large cohort of patients with cancer in the mobile tongue as such information can be important for treatment stratification of the individual patient, especially for patients with low-stage disease. In addition, we wanted to investigate whether an alternative scoring model with fewer options would compromise the prognostic value. One hundred fifty patients with oral tongue squamous cell carcinomas that were treated in curative intent and with available HE-stained tumor sections were included. We reclassified all tumors and performed univariate and multivariate survival analyses of histopathological and clinical variables. For the complete cohort, lymph node status, grade of differentiation, perineural infiltration, and lymphocytic infiltration were independent prognosticators. In the low-stage disease group, independent prognostic factors were tumor size, grade of differentiation, and lymphocytic infiltrate. For patients with low-stage disease, a histo-score combining the scores for tumor differentiation and lymphocytic infiltrate identified a group of patients with particularly low survival, as patients with moderately or poorly differentiated tumors and little lymphocytic infiltrate had a less favorable 5-year survival outcome than patients in the high-stage disease group. This study shows that a histo-score combining tumor differentiation and lymphocytic infiltration should be given special consideration in treatment planning. Our results also illustrate that many variables can be scored with fewer options than previously suggested to increase their reproducibility, and still maintain their prognostic value.en_US
dc.identifier.citationBjerkli, Hadler-Olsen, Nginamau, Laurvik, Søland, Costea, Uhlin-Hansen, Steigen. A combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue cancer. Virchows Archiv. 2020:1-8en_US
dc.identifier.cristinIDFRIDAID 1820043
dc.identifier.doi10.1007/s00428-020-02875-9
dc.identifier.issn0945-6317
dc.identifier.issn1432-2307
dc.identifier.urihttps://hdl.handle.net/10037/18913
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.ispartofBjerkli, I.H. (2020). Prognostic indicators of survival for patients with oral cavity squamous cell carcinoma in Norway. Outcomes in a retrospective, multicenter cohort, with special focus on oral tongue squamous cell carcinoma, 2005-2009. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19390>https://hdl.handle.net/10037/19390</a>
dc.relation.journalVirchows Archiv
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleA combined histo-score based on tumor differentiation and lymphocytic infiltrate is a robust prognostic marker for mobile tongue canceren_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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