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dc.contributor.authorCharles, Dolley
dc.contributor.authorBerg, Vivian
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorHuber, Sandra
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorRylander, Charlotta
dc.date.accessioned2020-12-21T14:55:32Z
dc.date.available2020-12-21T14:55:32Z
dc.date.issued2020-09-09
dc.description.abstract<i>Background</i> - Studies exploring the associations between perfluoroalkyl acids (PFAAs) and type 2 diabetes mellitus (T2DM) are rather limited and have reported conflicting results. All studies to date, including prospective ones, have relied on a single blood sample to study this association. Similarly, studies investigating how T2DM status may influence the longitudinal changes in PFAA concentrations have not been previously performed. As PFAA concentrations in humans have changed considerably over the last two decades, and as individuals diagnosed with T2DM usually undergo lifestyle changes that could influence these concentrations, a single blood sample may not necessarily reflect the life-time exposure to PFAA concentrations. Hence, repeated measurements from the same individuals will extend our understanding of how PFAAs are associated with T2DM. The present study, therefore, aimed to explore associations between pre- and post-diagnostic PFAA blood profiles and T2DM and assess factors associated with longitudinal changes in PFAAs in T2DM cases and controls.<p> <p><i>Methods</i> - Questionnaire data and blood samples from women participating in the Norwegian Women and Cancer study were used to conduct a nested case-control study among 46 T2DM cases matched to 85 non-diabetic controls. PFAAs were measured in blood samples collected prior to (2001/02) and after (2005/6) T2DM diagnosis. We investigated the association between PFAAs and incident and prevalent T2DM using conditional logistic regression. We assessed the longitudinal changes in PFAA concentrations within and between matched cases and controls using t-tests and linear regression models.<p> <p><i>Results</i> - We observed no significant associations between pre-diagnostic PFAA concentrations and T2DM incidence. Similar results were observed for the post-diagnostic PFAA concentrations and T2DM prevalence. Decrease over time in PFAA concentrations were observed for PFOA and ∑PFOS concentrations, whereas increase over time were observed for PFNA, PFDA and PFUnDA concentrations. Longitudinal trends in PFAA concentrations among T2DM cases were similar to the changes observed in controls.<p> <p><i>Conclusions</i> - The study did not find evidence of association between PFAAs and incident or prevalent T2DM. The longitudinal changes in PFAAs concentrations were not influenced by T2DM status.en_US
dc.identifier.citationCharles D, Berg V, Nøst TH, Huber SH, Sandanger TM, Rylander C. Pre- and post-diagnostic blood profiles of perfluoroalkyl acids in type 2 diabetes mellitus cases and controls. Environment International. 2020;145en_US
dc.identifier.cristinIDFRIDAID 1861203
dc.identifier.doihttps://doi.org/10.1016/j.envint.2020.106095
dc.identifier.issn0160-4120
dc.identifier.issn1873-6750
dc.identifier.urihttps://hdl.handle.net/10037/20117
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironment International
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titlePre- and post-diagnostic blood profiles of perfluoroalkyl acids in type 2 diabetes mellitus cases and controlsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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