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dc.contributor.authorWedekind, Roland
dc.contributor.authorKiss, Agneta
dc.contributor.authorKeski-Rahkonen, Pekka
dc.contributor.authorViallon, Vivian
dc.contributor.authorRothwell, Joseph A
dc.contributor.authorCross, Amanda J.
dc.contributor.authorRostgaard-Hansen, Agnetha Linn
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorJakszyn, Paula
dc.contributor.authorSchmidt, Julie A
dc.contributor.authorPala, Valeria
dc.contributor.authorVermeulen, Roel
dc.contributor.authorSchulze, Matthias B
dc.contributor.authorKühn, Tilman
dc.contributor.authorJohnson, Theron
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorPeppa, Eleni
dc.contributor.authorLa Vechia, Carlo
dc.contributor.authorMasala, Giovanna
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorWittenbecher, Clemens
dc.contributor.authorde Magistris, Maria Santucci
dc.contributor.authorDahm, Christina C
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorRomana Mancini, Francesca
dc.contributor.authorVainio, Elisabete Weiderpass
dc.contributor.authorGunter, Marc J.R.
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorScalbert, Augustin
dc.date.accessioned2021-03-23T22:20:54Z
dc.date.available2021-03-23T22:20:54Z
dc.date.issued2020-06-03
dc.description.abstract<p>Background - Acylcarnitines (ACs) play a major role in fatty acid metabolism and are potential markers of metabolic dysfunction with higher blood concentrations reported in obese and diabetic individuals. Diet, and in particular red and processed meat intake, has been shown to influence AC concentrations but data on the effect of meat consumption on AC concentrations is limited. <p>Objectives - To investigate the effect of red and processed meat intake on AC concentrations in plasma and urine using a randomized controlled trial with replication in an observational cohort. <p>Methods - In the randomized crossover trial, 12 volunteers successively consumed 2 different diets containing either pork or tofu for 3 d each. A panel of 44 ACs including several oxidized ACs was analyzed by LC-MS in plasma and urine samples collected after the 3-d period. ACs that were associated with pork intake were then measured in urine (n = 474) and serum samples (n = 451) from the European Prospective Investigation into Cancer and nutrition (EPIC) study and tested for associations with habitual red and processed meat intake derived from dietary questionnaires. <p>Results - In urine samples from the intervention study, pork intake was positively associated with concentrations of 18 short- and medium-chain ACs. Eleven of these were also positively associated with habitual red and processed meat intake in the EPIC cross-sectional study. In blood, C18:0 was positively associated with red meat intake in both the intervention study (q = 0.004, Student's t-test) and the cross-sectional study (q = 0.033, linear regression). <p>Conclusions - AC concentrations in urine and blood were associated with red meat intake in both a highly controlled intervention study and in subjects of a cross-sectional study. Our data on the role of meat intake on this important pathway of fatty acid and energy metabolism may help understanding the role of red meat consumption in the etiology of some chronic diseases. This trial was registered at Clinicaltrials.gov as NCT03354130.en_US
dc.identifier.citationWedekind, Kiss, Keski-Rahkonen, Viallon, Rothwell, Cross, Rostgaard-Hansen, Sandanger, Jakszyn, Schmidt, Pala, Vermeulen, Schulze, Kühn, Johnson, Trichopoulou, Peppa, La Vechia, Masala, Tumino, Sacerdote, Wittenbecher, de Magistris, Dahm, Severi, Romana Mancini, Vainio, Gunter, Huybrechts, Scalbert. A metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blood . American Journal of Clinical Nutrition. 2020en_US
dc.identifier.cristinIDFRIDAID 1898133
dc.identifier.doi10.1093/ajcn/nqaa140
dc.identifier.issn0002-9165
dc.identifier.issn1938-3207
dc.identifier.urihttps://hdl.handle.net/10037/20721
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalAmerican Journal of Clinical Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Endocrinology: 774en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en_US
dc.titleA metabolomic study of red and processed meat intake and acylcarnitine concentrations in human urine and blooden_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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