dc.contributor.author | Tveita, Anders Aune | |
dc.contributor.author | Rekvig, Ole Petter | |
dc.contributor.author | Zykova, Svetlana N. | |
dc.date.accessioned | 2009-09-30T12:33:04Z | |
dc.date.available | 2009-09-30T12:33:04Z | |
dc.date.issued | 2008-12-01 | |
dc.description.abstract | Lupus nephritis is a major contributor to morbidity and mortality in
systemic lupus erythematosus, but little is known about the
pathogenic processes that underlie the progressive decay in renal
function. A common finding in lupus nephritis is thickening of
glomerular basement membranes associated with immune complex
deposition. It has been speculated that alterations in the synthesis
or degradation of membrane components might contribute to such
changes, and thereby to initiation and progression of nephritis
through facilitation of immune complex deposition. Matrix metalloproteinases
(MMPs) are enzymes that are intimately involved in the
turnover of major glomerular basement membrane constituents,
including collagen IV and laminins. Alterations in the expression
and activity of MMPs have been described in a number of renal
diseases, suggesting their relevance to the pathogenesis of various
glomerulopathies. The same is true for their natural inhibitors, the
tissue inhibitor of metalloproteinase family. Recent data from our
group have identified an increase in proteolytic activity within the
glomerulus coinciding with the development of proteinuria in the
(NXB×NZW)F<sub>1</sub> mouse model of systemic lupus erythematosus.
Here we review current understanding of MMP/tissue inhibitor of
metalloproteinase function within the kidney, and discuss their
possible involvement in the development and progression of lupus
nephritis. | en |
dc.description | This article is part of Anders Aune Tveita's doctoral thesis, which is available in Munin at <a href=http://hdl.handle.net/10037/2898>http://hdl.handle.net/10037/2898</a> | |
dc.format.extent | 412214 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | Arthritis Research & Therapy 2008, 10:229 | en |
dc.identifier.uri | https://hdl.handle.net/10037/2144 | |
dc.identifier.urn | URN:NBN:no-uit_munin_1895 | |
dc.language.iso | eng | en |
dc.publisher | BioMed Central | en |
dc.rights.accessRights | openAccess | |
dc.subject | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759 | en |
dc.title | Glomerular matrix metalloproteinases and their regulators in the
pathogenesis of lupus nephritis | en |
dc.type | Journal article | en |
dc.type | Tidsskriftartikkel | en |
dc.type | Peer reviewed | en |