Vis enkel innførsel

dc.contributor.authorSamuelsen, Per-Jostein
dc.contributor.authorEggen, Anne Elise
dc.contributor.authorSteigen, Terje
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorKristensen, Andreas
dc.contributor.authorSkogsholm, Anne
dc.contributor.authorHolme, Elizabeth
dc.contributor.authorvan den Heuvel, Christian
dc.contributor.authorNordrehaug, Jan Erik
dc.contributor.authorBendz, Bjørn
dc.contributor.authorNilsen, Dennis W.T.
dc.contributor.authorBønaa, Kaare Harald
dc.date.accessioned2021-06-28T11:55:19Z
dc.date.available2021-06-28T11:55:19Z
dc.date.issued2021-03-04
dc.description.abstractIntroduction - Bleeding is a concern after percutaneous coronary intervention (PCI) and subsequent dual antiplatelet therapy (DAPT). We herein report the incidence and risk factors for major bleeding in the Norwegian Coronary Stent Trial (NORSTENT). <p> <p>Materials and methods - NORSTENT was a randomized, double blind, pragmatic trial among patients with acute coronary syndrome or stable coronary disease undergoing PCI during 2008–11. The patients (N = 9,013) were randomized to receive either a drug-eluting stent or a bare-metal stent, and were treated with at least nine months of DAPT. The patients were followed for a median of five years, with Bleeding Academic Research Consortium (BARC) 3–5 major bleeding as one of the safety endpoints. We estimated cumulative incidence of major bleeding by a competing risks model and risk factors through cause-specific Cox models. <p> <p>Results - The 12-month cumulative incidence of major bleeding was 2.3%. Independent risk factors for major bleeding were chronic kidney disease, low bodyweight (< 60 kilograms), diabetes mellitus, and advanced age (> 80 years). A myocardial infarction (MI) or PCI during follow-up increased the risk of major bleeding (HR = 1.67, 95% CI 1-29-2.15). <p> <p>Conclusions - The 12-month cumulative incidence of major bleeding in NORSTENT was higher than reported in previous, explanatory trials. This analysis strengthens the role of chronic kidney disease, advanced age, and low bodyweight as risk factors for major bleeding among patients receiving DAPT after PCI. The presence of diabetes mellitus or recurrent MI among patients is furthermore a signal of increased bleeding risk.en_US
dc.identifier.citationSamuelsen, Eggen, Steigen, Wilsgaard, Kristensen, Skogsholm, Holme, van den Heuvel, Nordrehaug, Bendz, Nilsen, Bønaa. Incidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT). PLOS ONE. 2021;16(3)en_US
dc.identifier.cristinIDFRIDAID 1918517
dc.identifier.doi10.1371/journal.pone.0247358
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/21585
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLOS ONE
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/?/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleIncidence and risk factors for major bleeding among patients undergoing percutaneous coronary intervention: Findings from the Norwegian Coronary Stent Trial (NORSTENT)en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel