Real-life evaluation of histologic scores for Ulcerative Colitis in remission
Permanent lenke
https://hdl.handle.net/10037/21739Dato
2021-03-08Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Arkteg, Christian Børde; Sørbye, Sveinung Wergeland; Riis, Lene Buhl; Dalen, Stig Manfred; Florholmen, Jon; Goll, RasmusSammendrag
Method - Mucosal biopsies from 41 UC patients in clinical and endoscopic remission were collected as part of a larger study on UC. Three pathologists blinded to the patients’ clinical status evaluated them using Geboes score (GS), Nancy Index (NI) and Robarts Histopathological Index (RHI). We calculated the agreement between the pathologists using Inter-class correlation (ICC) and visualized it with ICC-plots and Bland-Altman plots. Association between clinical factors and histological category were analysed by Fisher’s exact test.
Results - The ICC value for GS, RHI and NI were 0.85, 0.73 and 0.70 respectively. The limits of agreement were ±6.1, ±4.0 and ±1.4, for GS, RHI and NI, respectively. Mayo endoscopic subgrade and UC clinical score did not show association with any histological scores. Despite clinical and endoscopic remission 7–35% of the patients displayed histological inflammation on a level classified as active disease, depending on the index and cut-off.
Conclusion - A substantial amount of UC patients in clinical and endoscopic remission display inflammation on a histological level, but the ability to classify these patients accurately and consistently could be improved.