Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25
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https://hdl.handle.net/10037/23388Dato
2021-06-14Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Monnè, Magnus; Nikiforov, Andrey; Heiland, Ines; Agrimi, Gennaro; Ziegler, Mathias; Palmieri, FerdinandoSammendrag
Subcellular compartmentation is a fundamental property of eukaryotic cells. Communication and metabolic and regulatory interconnectivity between organelles require that solutes
can be transported across their surrounding membranes. Indeed, in mammals, there are hundreds
of genes encoding solute carriers (SLCs) which mediate the selective transport of molecules such
as nucleotides, amino acids, and sugars across biological membranes. Research over many years
has identified the localization and preferred substrates of a large variety of SLCs. Of particular
interest has been the SLC25 family, which includes carriers embedded in the inner membrane of
mitochondria to secure the supply of these organelles with major metabolic intermediates and coenzymes. The substrate specificity of many of these carriers has been established in the past. However,
the route by which animal mitochondria are supplied with NAD+ had long remained obscure.
Only just recently, the existence of a human mitochondrial NAD+
carrier was firmly established.
With the realization that SLC25A51 (or MCART1) represents the major mitochondrial NAD+
carrier
in mammals, a long-standing mystery in NAD+ biology has been resolved. Here, we summarize the
functional importance and structural features of this carrier as well as the key observations leading
to its discovery.
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Monnè, Nikiforov, Heiland, Agrimi, Ziegler, Palmieri. Welcome to the Family: Identification of the NAD+ Transporter of Animal Mitochondria as Member of the Solute Carrier Family SLC25. Biomolecules. 2021Metadata
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