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dc.contributor.authorKliemann, Nathalie
dc.contributor.authorViallon, Vivian
dc.contributor.authorMurphy, Neil
dc.contributor.authorBeeken, Rebecca J.
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorAssi, Nada
dc.contributor.authorvan Roekel, Eline H.
dc.contributor.authorSchmidt, Julie A.
dc.contributor.authorBorch, Kristin Benjaminsen
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorRosendahl, Ann H.
dc.contributor.authorSartor, Hanna
dc.contributor.authorHuerta, José María
dc.contributor.authorTjønneland, Anne
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorGicquiau, Audrey
dc.contributor.authorAchaintre, David
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorTsilidis, Konstantinos K.
dc.contributor.authorMasala, Giovanna
dc.contributor.authorPanico, Salvatore
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorFortner, Renée T.
dc.contributor.authorVan Guelpen, Bethany
dc.contributor.authorDossus, Laure
dc.contributor.authorScalbert, Augustin
dc.contributor.authorKeun, Hector C.
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorJenab, Mazda
dc.contributor.authorJohansson, Mattias
dc.contributor.authorFerrari, Pietro
dc.contributor.authorGunter, Marc J.
dc.date.accessioned2022-02-15T09:57:12Z
dc.date.available2022-02-15T09:57:12Z
dc.date.issued2021-04-30
dc.description.abstractBackground: The mechanisms underlying the obesity-cancer relationship are incompletely understood. This study aimed to characterise metabolic signatures of greater body size and to investigate their association with two obesity-related malignancies, endometrial and colorectal cancers, and with weight loss within the context of an intervention study.<p> <p>Methods: Targeted mass spectrometry metabolomics data from 4326 participants enrolled in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort and 17 individuals from a single-arm pilot weight loss intervention (Intercept) were used in this analysis. Metabolic signatures of body size were first determined in discovery (N = 3029) and replication (N = 1297) sets among EPIC participants by testing the associations between 129 metabolites and body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) using linear regression models followed by partial least squares analyses. Conditional logistic regression models assessed the associations between the metabolic signatures with endometrial (N = 635 cases and 648 controls) and colorectal (N = 423 cases and 423 controls) cancer risk using nested case-control studies in EPIC. Pearson correlation between changes in the metabolic signatures and weight loss was tested among Intercept participants.<p><p>Results: After adjustment for multiple comparisons, greater BMI, WC, and WHR were associated with higher levels of valine, isoleucine, glutamate, PC aa C38:3, and PC aa C38:4 and with lower levels of asparagine, glutamine, glycine, serine, lysoPC C17:0, lysoPC C18:1, lysoPC C18:2, PC aa C42:0, PC ae C34:3, PC ae C40:5, and PC ae C42:5. The metabolic signature of BMI (OR1<sub>-sd</sub> 1.50, 95% CI 1.30–1.74), WC (OR1<sub>-sd</sub> 1.46, 95% CI 1.27–1.69), and WHR (OR1<sub>-sd</sub> 1.54, 95% CI 1.33–1.79) were each associated with endometrial cancer risk. Risk of colorectal cancer was positively associated with the metabolic signature of WHR (OR1<sub>-sd</sub>: 1.26, 95% CI 1.07–1.49). In the Intercept study, a positive correlation was observed between weight loss and changes in the metabolic signatures of BMI (r = 0.5, 95% CI 0.06–0.94, p = 0.03), WC (r = 0.5, 95% CI 0.05–0.94, p = 0.03), and WHR (r = 0.6, 95% CI 0.32–0.87, p = 0.01).<p> <p>Conclusions: Obesity is associated with a distinct metabolic signature comprising changes in levels of specific amino acids and lipids which is positively associated with both colorectal and endometrial cancer and is potentially reversible following weight loss.en_US
dc.identifier.citationKliemann, N., Viallon, V., Murphy, N. et al. Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition. BMC Med 19, 101 (2021).en_US
dc.identifier.cristinIDFRIDAID 1989507
dc.identifier.doi10.1186/s12916-021-01970-1
dc.identifier.issn1741-7015
dc.identifier.urihttps://hdl.handle.net/10037/24051
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleMetabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutritionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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