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dc.contributor.authorPettersen, Veronika K.
dc.contributor.authorAntunes, Luis Caetano Martha
dc.contributor.authorDufour, A
dc.contributor.authorArrieta, Marie-Claire
dc.date.accessioned2022-02-17T12:52:15Z
dc.date.available2022-02-17T12:52:15Z
dc.date.issued2021-12-20
dc.description.abstractHumans have a long-standing coexistence with microorganisms. In particular, the microbial community that populates the human gastrointestinal tract has emerged as a critical player in governing human health and disease. DNA and RNA sequencing techniques that map taxonomical composition and genomic potential of the gut community have become invaluable for microbiome research. However, deriving a biochemical understanding of how activities of the gut microbiome shape host development and physiology requires an expanded experimental design that goes beyond these approaches. In this review, we explore advances in high-throughput techniques based on liquid chromatography– mass spectrometry. These omics methods for the identification of proteins and metabolites have enabled direct characterisation of gut microbiome functions and the crosstalk with the host. We discuss current metaproteomics and metabolomics workflows for producing functional profiles, the existing methodological challenges and limitations, and recent studies utilising these techniques with a special focus on early life gut microbiome.en_US
dc.identifier.citationPettersen V, Antunes, Dufour A, Arrieta M. Inferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomics. Computational and Structural Biotechnology Journal. 2021en_US
dc.identifier.cristinIDFRIDAID 1972061
dc.identifier.doihttps://doi.org/10.1016/j.csbj.2021.12.012
dc.identifier.issn2001-0370
dc.identifier.urihttps://hdl.handle.net/10037/24081
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalComputational and Structural Biotechnology Journal
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleInferring early-life host and microbiome functions by mass spectrometry-based metaproteomics and metabolomicsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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