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dc.contributor.authorLarsen, Terje
dc.contributor.authorJansen, Kirsten
dc.date.accessioned2022-03-07T09:51:03Z
dc.date.available2022-03-07T09:51:03Z
dc.date.issued2021-11-10
dc.description.abstractThis review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The general idea is that the expansion of adipocytes during the development of obesity gives rise to unhealthy adipose tissue, characterized by low-grade inflammation and the release of proinflammatory adipokines and fatty acids (FAs). This condition, in turn, causes systemic inflammation and elevated FA concentrations in the circulation, which links obesity to several pathologies, including impaired insulin signaling in cardiac muscle and a subsequent shift in myocardial substrate oxidation in favor of FAs and reduced cardiac efficiency. This review also argues that efforts to prevent obesity-related cardiometabolic disease should focus on antiobesogenic strategies to restore normal adipose tissue metabolism.en_US
dc.identifier.citationLarsen, Jansen. Impact of obesity-related inflammation on cardiac metabolism and function. Journal of Lipid and Atherosclerosis (JLA). 2021en_US
dc.identifier.cristinIDFRIDAID 1998734
dc.identifier.doi10.12997/jla.2021.10.1.8
dc.identifier.issn2287-2892
dc.identifier.issn2288-2561
dc.identifier.urihttps://hdl.handle.net/10037/24289
dc.language.isoengen_US
dc.publisherKorean Society of Lipidology and Atherosclerosisen_US
dc.relation.journalJournal of Lipid and Atherosclerosis (JLA)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Korean Society of Lipid and Atherosclerosisen_US
dc.titleImpact of obesity-related inflammation on cardiac metabolism and functionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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