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dc.contributor.authorDos Santos, Mélanie
dc.contributor.authorLicaj, Idlir
dc.contributor.authorBellera, Carine
dc.contributor.authorCany, Laurent
dc.contributor.authorBinarelli, Giulia
dc.contributor.authorSoubeyran, Pierre
dc.contributor.authorJoly, Florence
dc.date.accessioned2022-03-09T10:30:43Z
dc.date.available2022-03-09T10:30:43Z
dc.date.issued2021-12-07
dc.description.abstractOlder cancer patients are vulnerable to chemotherapy-related cognitive impairment. We prospectively evaluated cognitive impairment and its predictive factors during first-line chemotherapy in elderly cancer patients (≥70 years). Cognitive function was evaluated by the Mini-Mental State Examination (MMSE) with adjusted scores for age and sociocultural level. Multidimensional geriatric assessment was performed at baseline and during chemotherapy including the MMSE, Instrumental Activities in Daily Living (IADL), Mini-Nutritional Assessment (MNA), and the Geriatric Depression Scale (GDS15). Quality of life (QoL) was evaluated using the European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire (QLQ-C30). Of 364 patients included, 310 had two MMSE evaluations including one at baseline and were assessed. Among these patients, 86 (27.7%) had abnormal MMSE, 195 (62.9%) abnormal MNA, 223 (71.9%) abnormal IADL, and 137 (43.1%) had depressive symptoms at baseline. MMSE impairment during chemotherapy was observed in 58 (18.7%) patients. Abnormal baseline MNA (odds ratio (OR) = 1.87, p = 0.021) and MMSE (OR = 2.58, p = 0.022) were independent predictive factors of MMSE impairment. These results suggest that pre-existing cognitive impairment and malnutrition are predictive factors for cognitive decline during chemotherapy in elderly cancer patients. Detection and management of these risk factors should be systematically considered in this population before starting chemotherapy.en_US
dc.identifier.citationDos Santos, Licaj, Bellera, Cany, Binarelli, Soubeyran, Joly. Cognitive impairment in older cancer patients treated with first-line chemotherapy. Cancers. 2021;13(24)en_US
dc.identifier.cristinIDFRIDAID 1971264
dc.identifier.doi10.3390/cancers13246171
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10037/24343
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalCancers
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleCognitive impairment in older cancer patients treated with first-line chemotherapyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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