Show simple item record

dc.contributor.authorPapadimitriou, Nikos
dc.contributor.authorBouras, Emmanouil
dc.contributor.authorvan den Brandt, Piet A.
dc.contributor.authorMuller, David C.
dc.contributor.authorPapadopoulou, Areti
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorCritselis, Elena
dc.contributor.authorGunter, Marc
dc.contributor.authorVineis, Paolo
dc.contributor.authorFerrari, Pietro
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBastide, Nadia
dc.contributor.authorMerritt, Melissa A.
dc.contributor.authorLopez, David S.
dc.contributor.authorBergmann, Manuela M.
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorSchulze, Matthias
dc.contributor.authorSkeie, Guri
dc.contributor.authorSrour, Bernard
dc.contributor.authorEriksen, Anne Kirstine
dc.contributor.authorBoden, Stina
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorNøst, Therese Haugdahl
dc.contributor.authorLukic, Marko
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorEricson, Ulrika
dc.contributor.authorHuerta, José-Maria
dc.contributor.authorDahm, Christina C.
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorAmiano, Pilar
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorArdanaz, Eva
dc.contributor.authorBerntsson, Jonna
dc.contributor.authorSánchez, Maria-Jose
dc.contributor.authorTumino, Rosario
dc.contributor.authorPanico, Salvatore
dc.contributor.authorKatzke, Verena
dc.contributor.authorJakszyn, Paula
dc.contributor.authorMasala, Giovanna
dc.contributor.authorDerksen, Jeroen W.G.
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorCross, Amanda J.
dc.contributor.authorRiboli, Ellio
dc.contributor.authorTzoulaki, Ioanna
dc.contributor.authorTsilidis, Konstantinos K.
dc.date.accessioned2022-03-16T11:30:26Z
dc.date.available2022-03-16T11:30:26Z
dc.date.issued2021-04-24
dc.description.abstractBackground & Aims - Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk.<p> <p>Methods - The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci.<p> <p>Results - In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04–1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02–1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04–1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93–0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90–0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90–0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92–0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94–0.99), riboflavin (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97), beta carotene (HR per 1-SD increment in intake, 0.96; 95% CI, 0.93–0.98), and total protein (HR per 1-SD increment in intake, 0.94; 95% CI, 0.92–0.97). None of the gene-nutrient interactions were significant after adjustment for multiple comparisons.<p> <p>Conclusions - Our findings confirm a positive association for alcohol and an inverse association for dairy products and calcium with CRC risk, and also suggest a lower risk at higher dietary intakes of phosphorus, magnesium, potassium, riboflavin, beta carotene, and total protein.en_US
dc.identifier.citationPapadimitriou, Bouras, van den Brandt, Muller, Papadopoulou, Heath, Critselis, Gunter, Vineis, Ferrari, Weiderpass, Boeing, Bastide, Merritt, Lopez, Bergmann, Perez-Cornago, Schulze, Skeie, Srour, Eriksen, Boden, Johansson, Nøst, Lukic M, Ricceri, Ericson, Huerta, Dahm, Agnoli, Amiano, Tjønneland, Barricarte, Bueno-de-Mesquita, Ardanaz, Berntsson, Sánchez, Tumino, Panico, Katzke, Jakszyn, Masala, Derksen, Quirós, Severi, Cross, Riboli, Tzoulaki, Tsilidis. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC. Clinical Gastroenterology and Hepatology. 2021en_US
dc.identifier.cristinIDFRIDAID 2007149
dc.identifier.doi10.1016/j.cgh.2021.04.028
dc.identifier.issn1542-3565
dc.identifier.issn1542-7714
dc.identifier.urihttps://hdl.handle.net/10037/24425
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalClinical Gastroenterology and Hepatology
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2021 by the AGA Instituteen_US
dc.titleA Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPICen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record