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dc.contributor.authorDietrichs, Erik Sveberg
dc.contributor.authorSmith, Godfrey L
dc.date.accessioned2022-03-24T12:00:15Z
dc.date.available2022-03-24T12:00:15Z
dc.date.issued2022-03-16
dc.description.abstract<b><p>Background:</b> The U.S. Food and Drug Administration (FDA) has stated that citalopram and escitalopram should not be used at daily doses above 40 mg/20 mg due to risk for development of fatal ventricular arrhythmias like torsade de pointes (TdP). Yet, supratherapeutic serum concentrations of citalopram are common and predicting patients at risk for TdP is of high clinical value. Accordingly, we investigated whether QRS/QTc; developed for predicting TdP in hypothermic patients could be used in citalopram intoxication. <b><p>Methods:</b> A total of 16 publications describing patients suffering from complications due to citalopram or escitalopram treatment, or intoxication with the same substances, were included after a systematic search. The main criterion for inclusion was admission ECG, either with given QRS and QTc values or with attached ECG-files that enabled calculation. <b><p>Results: </b>QRS/QTc rather that QTc alone emerged as a marker of ventricular arrhythmia in the 16 included case reports, with highly significant (<i>p</i> < 0.0005) lower values in patients displaying ventricular arrhythmias. <b><p>Conclusion:</b> Citalopram and escitalopram are extensively used in treatment of depressive disorders, and a large proportion of patients have supratherapeutic serum concentrations. Calculation of QRS/QTc in available case reports show that this novel ECG-marker has potential to predict patients at risk for developing ventricular arrhythmias.en_US
dc.identifier.citationDietrichs, Smith. Prediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxication. Frontiers in medicine. 2022en_US
dc.identifier.cristinIDFRIDAID 2010147
dc.identifier.doi10.3389/fmed.2022.866454
dc.identifier.issn2296-858X
dc.identifier.urihttps://hdl.handle.net/10037/24544
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titlePrediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxicationen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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