Classical and noncanonical functions of miRNAs in cancers
Permanent lenke
https://hdl.handle.net/10037/24567Dato
2021-10-30Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the widespread differential expression of miRNAs in malignancy are exemplified by their location in cancer-associated genomic regions, epigenetic mechanisms, transcriptional dysregulation, chemical modifications and editing, and alterations in miRNA biogenesis proteins. The classical miRNA function is synonymous with post-transcriptional repression of target protein genes. However, several studies have reported miRNAs functioning outside this paradigm and some of these novel modes of regulation of gene expression have been implicated in cancers. Here, we summarize key aspects of miRNA involvement in cancer, with a special focus on these lesser-studied mechanisms of action.
Forlag
ElsevierSitering
Dragomir, Knutsen, Calin. Classical and noncanonical functions of miRNAs in cancers. Trends in Genetics. 2021Metadata
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Copyright 2021 The Author(s)