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dc.contributor.authorLamark, Trond
dc.contributor.authorJohansen, Terje
dc.date.accessioned2022-03-29T10:58:48Z
dc.date.available2022-03-29T10:58:48Z
dc.date.issued2021-06-21
dc.description.abstractSelective autophagy is the lysosomal degradation of specific intracellular components sequestered into autophagosomes, late endosomes, or lysosomes through the activity of selective autophagy receptors (SARs). SARs interact with autophagy-related (ATG)8 family proteins via sequence motifs called LC3-interacting region (LIR) motifs in vertebrates and Atg8-interacting motifs (AIMs) in yeast and plants. SARs can be divided into two broad groups: soluble or membrane bound. Cargo or substrate selection may be independent or dependent of ubiquitin labeling of the cargo. In this review, we discuss mechanisms of mammalian selective autophagy with a focus on the unifying principles employed in substrate recognition, interaction with the forming autophagosome via LIR-ATG8 interactions, and the recruitment of core autophagy components for efficient autophagosome formation on the substrate.en_US
dc.identifier.citationLamark, Johansen. Mechanisms of Selective Autophagy. Annual Review of Cell and Developmental Biology. 2021;37:143-169en_US
dc.identifier.cristinIDFRIDAID 1951141
dc.identifier.doi10.1146/annurev-cellbio-120219-035530
dc.identifier.issn1081-0706
dc.identifier.issn1530-8995
dc.identifier.urihttps://hdl.handle.net/10037/24623
dc.language.isoengen_US
dc.publisherAnnual Reviewsen_US
dc.relation.journalAnnual Review of Cell and Developmental Biology
dc.relation.projectIDNorges forskningsråd: 249884en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleMechanisms of Selective Autophagyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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