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dc.contributor.authorSluijter, Joost Petrus Geradus
dc.contributor.authorDavidson, Sean Michael
dc.contributor.authorBoulanger, Chantal M
dc.contributor.authorBuzas, Edit Iren
dc.contributor.authorDe Kleijn, Dominique P.V.
dc.contributor.authorEngel, Felix Benedikt
dc.contributor.authorGiricz, Zoltán
dc.contributor.authorHausenloy, Derek J.
dc.contributor.authorKishore, Raj
dc.contributor.authorLecour, Sandrine
dc.contributor.authorLeor, Jonathan
dc.contributor.authorMadonna, Rosalinda
dc.contributor.authorPerrino, Cinzia
dc.contributor.authorPrunier, Fabrice
dc.contributor.authorSahoo, Susmita
dc.contributor.authorSchiffelers, Ray Michel
dc.contributor.authorSchulz, Rainer
dc.contributor.authorVan Laake, Linda Wilhelmina
dc.contributor.authorYtrehus, Kirsti
dc.contributor.authorFerdinandy, Péter
dc.date.accessioned2022-04-27T08:58:29Z
dc.date.available2022-04-27T08:58:29Z
dc.date.issued2017-11-02
dc.description.abstractExtracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient cells to modify cellular activity. EVs powerfully stimulate angiogenesis, and can protect the heart against myocardial infarction. They also appear to mediate some of the paracrine effects of cells, and have therefore been proposed as a potential alternative to cell-based regenerative therapies. Moreover, EVs of different sources may be useful biomarkers of cardiovascular disease identities. However, the methods used for the detection and isolation of EVs have several limitations and vary widely between studies, leading to uncertainties regarding the exact population of EVs studied and how to interpret the data. The number of publications in the exosome and MV field has been increasing exponentially in recent years and, therefore, in this ESC Working Group Position Paper, the overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart. This should help to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.en_US
dc.identifier.citationSluijter JPG, Davidson SM, Boulanger CM, Buzas, De Kleijn DP, Engel FB, Giricz Z, Hausenloy DJ, Kishore, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers, Schulz R, Van Laake LW, Ytrehus k, Ferdinandy P. Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology. Cardiovascular Research (CVR). 2018;114(1):19-34en_US
dc.identifier.cristinIDFRIDAID 1625887
dc.identifier.doi10.1093/cvr/cvx211
dc.identifier.issn0008-6363
dc.identifier.issn1755-3245
dc.identifier.urihttps://hdl.handle.net/10037/24903
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalCardiovascular Research (CVR)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/725229/EU/Extracellular Vesicle-Inspired CArdiac Repair/EVICARE/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2017 The Author(s)en_US
dc.titleExtracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiologyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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