dc.contributor.author | Ma, Seung-Hyun | |
dc.contributor.author | Jung, Woohyun | |
dc.contributor.author | Weiderpass, Elisabete | |
dc.contributor.author | Jang, Jieun | |
dc.contributor.author | Hwang, Yunji | |
dc.contributor.author | Ahn, Chunghyun | |
dc.contributor.author | Ko, Kwang-Pil | |
dc.contributor.author | Chang, Soung-Hoon | |
dc.contributor.author | Shin, Hai-Rim | |
dc.contributor.author | Yoo, Keun-Young | |
dc.contributor.author | Park, Sue K. | |
dc.date.accessioned | 2022-04-28T11:07:07Z | |
dc.date.available | 2022-04-28T11:07:07Z | |
dc.date.issued | 2015-09-17 | |
dc.description.abstract | Background: Helicobacter pylori are major carcinogen of gastric cancer, but the associations among gastric cancer, H. pylori
infection status, and alcohol consumption are not fully described. This study aimed to clarify how H. pylori infection status affects
the association between alcohol consumption and gastric cancer risk.<p>
<p>Methods: We selected 949 case–cohort participants from the 18 863 Korean Multi-center Cancer Cohort (KMCC) populations.
Gastric cancer incidence inside and outside of the subcohort were 12 and 254 cases, respectively. Seropositivities for CagA, VacA,
and H. pylori infection were determined by performing immunoblot assays. Weighted Cox regression models were used to
calculate hazard ratios and 95% confidence intervals (CIs).<p>
<p>Results: Relative to non-drinking, heavy drinking (X7 times a week), and binge drinking (X55 g alcohol intake per occasion)
showed a 3.48-fold (95% CI, 1.13–10.73) and 3.27-fold (95% CI, 1.01–10.56) higher risk in subjects not previously infected by
H. pylori. There was no significant association between drinking pattern and gastric cancer risk in H. pylori IgG seropositive
subjects. An increased risk for gastric cancer in heavy- and binge-drinking subjects were also present in subjects not infected by
CagA- or VacA-secreting H. pylori.<p>
<p>Conclusions: Heavy and binge alcohol consumption is an important risk factor related to an increasing incidence of gastric cancer
in a population not infected by H. pylori. | en_US |
dc.identifier.citation | Ma, Jung, Weiderpass E, Jang, Hwang, Ahn, Ko, Chang, Shin, Yoo K, Park SK. Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status. British Journal of Cancer. 2015;113(9):1381-1388 | en_US |
dc.identifier.cristinID | FRIDAID 1318355 | |
dc.identifier.doi | 10.1038/bjc.2015.333 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.issn | 1532-1827 | |
dc.identifier.uri | https://hdl.handle.net/10037/24928 | |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.journal | British Journal of Cancer | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2015 Cancer Research UK | en_US |
dc.title | Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |