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dc.contributor.authorGraf, S
dc.contributor.authorLester, Susan
dc.contributor.authorNossent, Johannes C
dc.contributor.authorHill, C
dc.contributor.authorProudman, S. M
dc.contributor.authorLee, A
dc.contributor.authorRischmueller, Maureen
dc.date.accessioned2022-05-05T06:50:11Z
dc.date.available2022-05-05T06:50:11Z
dc.date.issued2012-02-07
dc.description.abstractIntroduction: Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether low CN of the FCGR3B gene is associated with susceptibility to RA.<p> <p>Method: The FCGR3B CN was determined using a custom Taqman® CN assay (Hs04211858; Applied Biosystems, Foster City, CA, USA) in 197 RA patients, recruited from a tertiary setting, and in 162 population matched controls. Odds ratios for low CN (< 2) and high CN (> 2), both relative to the normal diploid 2CN, were estimated by logistic regression.<p> <p>Results: A significant association between RA and low FCGR3B CN was observed, with frequencies of 13.7% in RA patients compared with 6.2% in controls (odds ratio 2.5, 95% confidence interval 1.2 to 5.4, P = 0.017). No association was observed between low CN and the presence of rheumatoid factor, anti-cyclic citrullinated peptide antibodies or radiographic erosions in RA patients. A meta-analysis including six previous studies confirmed an association between RA and low FCGR3B CN (odds ratio 1.47, 95% confidence interval 1.13 to 1.92, P = 0.004).<p> <p>Conclusions: The present study confirms that a low CN of the FCGR3B gene is associated with susceptibility to RA. The association may be stronger in patients recruited from a tertiary setting, which may relate to disease severity and/or complications. The mechanism of susceptibility remains unclear and further study is required.en_US
dc.identifier.citationGraf S, Lester S, Nossent JC, Hill C, Proudman SM, Lee A, Rischmueller M. Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis. Arthritis Research & Therapy. 2012;14(1)
dc.identifier.cristinIDFRIDAID 958789
dc.identifier.doi10.1186/ar3731
dc.identifier.issn1478-6354
dc.identifier.issn1478-6362
dc.identifier.urihttps://hdl.handle.net/10037/25012
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalArthritis Research & Therapy
dc.rights.holderCopyright 2012 The Author(s)en_US
dc.titleLow copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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