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dc.contributor.advisorCauzzo, Jennifer
dc.contributor.advisorŠkalko-Basnet, Nataša
dc.contributor.authorMork, Silje
dc.date.accessioned2022-05-18T09:42:52Z
dc.date.available2022-05-18T09:42:52Z
dc.date.issued2020-05-14en
dc.description.abstractLiposomes as drug delivery systems exhibit great potential to deliver active molecules to the targeted site depending on their various characteristics. However, these characteristics are dependent on the manufacturing procedures applied to prepare liposomes. Especially difficult is assurance of reproducible production in large volumes. Therefore an efficient up-scalable method for production of liposomes is needed. A microfluidizer has shown to be able to prepare large volumes of liposomes, however there is not an easy set up on this machine that guarantees reproducible formulations. For such a method, screening of liposome characteristics are important, and adding fluorophores to liposomes increases the ability to follow not only their characteristics, but also fate in organisms via imaging. However for fluorescent imaging to be useful and reliable, fluorescently labeled liposomes must exhibit the same behavior as the plain liposome. Here, optimization of microfluidizer parameters for the production of fluorescent liposomes for cell uptake imaging and biological activity testing on cell cultures is carried out.en_US
dc.identifier.urihttps://hdl.handle.net/10037/25161
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universitetno
dc.publisherUiT The Arctic University of Norwayen
dc.rights.holderCopyright 2020 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subject.courseIDFAR-3911
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Biofarmasi: 736en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Biopharmacy: 736en_US
dc.titleMicrofluidized liposomes for cellular uptake imaging: Optimizationen_US
dc.typeMastergradsoppgaveno
dc.typeMaster thesisen


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Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)