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dc.contributor.advisorYtrebø, Lars Marius
dc.contributor.advisorHodges, Stephen
dc.contributor.advisorFuskevåg, Ole-Martin
dc.contributor.authorJakobsen, Kjellbjørn
dc.date.accessioned2022-05-23T08:34:05Z
dc.date.available2022-05-23T08:34:05Z
dc.date.issued2021-05-23en
dc.description.abstractIntroduction Perioperative acute kidney injury (AKI) is associated with increased morbidity and mortality. Estimated glomerular filtration rate (eGFR) is routinely used to monitor renal function. This is an imprecise tool in the non-steady state condition and much kidney function can be lost before it is detectable by the eGFR method. A continuous low-dose infusion of iohexol has been proposed as a potentially valuable method of measuring GFR (mGFR). This novel method was tested in patients undergoing major abdominal cancer surgery. The aim for this thesis was to evaluate the feasibility of using iohexol to measure GFR, and to present data from a clinical feasibility study where the exogenous substance iohexol was applied for measurement of GFR. Methods Clinical observational study of a preoperative single iohexol injection and a continuous low-dose infusion of iohexol for 72 hours in four patients undergoing robot-assisted colorectal cancer surgery. Plasma iohexol clearances were measured at timed intervals and compared to eGFR calculated from creatinine and cystatin C levels. Results eGFRcystatin C demonstrated a different variability from that of mGFRiohexol, while eGFRcreatinine showed very little variation for the duration of the study. Furthermore, eGFRcreatinine and eGFRcystatin C underestimated actual measured GFR. Conclusions Measurement of renal function in the perioperative setting is feasible with single injection and continuous low-dose infusion of iohexol. Iohexol plasma clearance should be applied when accurate GFR measurements are required.en_US
dc.description25.05.22: Utsettes ytterligere 1 år etter ønske fra student/IHTI
dc.identifier.urihttps://hdl.handle.net/10037/25251
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universitetno
dc.publisherUiT The Arctic University of Norwayen
dc.rights.holderCopyright 2021 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)en_US
dc.subject.courseIDMED-3950
dc.subjectGlomerular filtration rateen_US
dc.subjectIohexolen_US
dc.subjectPerioperative careen_US
dc.titleThe use of iohexol as a marker to measure glomerular filtration rate in the non-steady state of patients undergoing robot-assisted colorectal surgeryen_US
dc.typeMaster thesisen
dc.typeMastergradsoppgaveno


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