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dc.contributor.authorDi Castelnuovo, Augusto
dc.contributor.authorCostanzo, Simona
dc.contributor.authorBonaccio, Marialaura
dc.contributor.authorMcElduff, Patrick
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorMännistö, Satu
dc.contributor.authorMoitry, Marie
dc.contributor.authorFerrières, Jean
dc.contributor.authorDallongeville, Jean
dc.contributor.authorThorand, Barbara
dc.contributor.authorBrenner, Hermann
dc.contributor.authorFerrario, Marco
dc.contributor.authorVeronesi, Giovanni
dc.contributor.authorPettenuzzo, Emanuela
dc.contributor.authorTamosiunas, Abdonas
dc.contributor.authorNjølstad, Inger
dc.contributor.authorDrygas, Wojciech
dc.contributor.authorNikitin, Yuri
dc.contributor.authorSöderberg, Stefan
dc.contributor.authorKee, Frank
dc.contributor.authorGrassi, Guido
dc.contributor.authorWestermann, Dirk
dc.contributor.authorSchrage, Benedikt
dc.contributor.authorDabboura, Salim
dc.contributor.authorZeller, Tanja
dc.contributor.authorKuulasmaa, Kari
dc.contributor.authorBlankenberg, Stefan
dc.contributor.authorDonati, Maria Benedetta
dc.contributor.authorde Gaetano, Giovanni
dc.contributor.authorIacoviello, Licia
dc.date.accessioned2022-08-16T06:29:14Z
dc.date.available2022-08-16T06:29:14Z
dc.date.issued2021-06-09
dc.description.abstractAim To test the association of alcohol consumption with total and cause-specific mortality risk. Design Prospective observational multi-centre population-based study. Setting Sixteen cohorts (15 from Europe) in the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project. Participants A total of 142 960 individuals (mean age 50 ± 13 years, 53.9% men). Measurements Average alcohol intake by food frequency questionnaire, total and cause-specific mortality. Findings In comparison with life-time abstainers, consumption of alcohol less than 10 g/day was associated with an average 11% [95% confidence interval (CI) = 7–14%] reduction in the risk of total mortality, while intake > 20 g/day was associated with a 13% (95% CI = 7–20%) increase in the risk of total mortality. Comparable findings were observed for cardiovascular (CV) deaths. With regard to cancer, drinking up to 10 g/day was not associated with either mortality risk reduction or increase, while alcohol intake > 20 g/day was associated with a 22% (95% CI = 10–35%) increased risk of mortality. The association of alcohol with fatal outcomes was similar in men and women, differed somewhat between countries and was more apparent in individuals preferring wine, suggesting that benefits may not be due to ethanol but other ingredients. Mediation analysis showed that high-density lipoprotein cholesterol explained 2.9 and 18.7% of the association between low alcohol intake and total as well as CV mortality, respectively. Conclusions In comparison with life-time abstainers, consuming less than one drink per day (nadir at 5 g/day) was associated with a reduced risk of total, cardiovascular and other causes mortality, except cancer. Intake of more than two drinks per day was associated with an increased risk of total, cardiovascular and especially cancer mortality.en_US
dc.identifier.citationDi Castelnuovo, Costanzo, Bonaccio, McElduff, Linneberg, Salomaa, Männistö, Moitry, Ferrières, Dallongeville, Thorand, Brenner, Ferrario, Veronesi, Pettenuzzo, Tamosiunas, Njølstad, Drygas, Nikitin, Söderberg, Kee, Grassi, Westermann, Schrage, Dabboura, Zeller, Kuulasmaa, Blankenberg, Donati, de Gaetano, Iacoviello. Alcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based study. Addiction. 2022;117(2):312-325en_US
dc.identifier.cristinIDFRIDAID 2021855
dc.identifier.doi10.1111/add.15593
dc.identifier.issn0965-2140
dc.identifier.issn1360-0443
dc.identifier.urihttps://hdl.handle.net/10037/26203
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalAddiction
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/278913/EU/Biomarker for Cardiovascular Risk Assessment in Europe/BIOMARCARE/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-HEALTH/242244/EU/In-depth exploration of health factors affecting the elderly/CHANCES/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleAlcohol intake and total mortality in 142 960 individuals from the MORGAM Project: a population-based studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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