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dc.contributor.authorArranz, Lorena
dc.date.accessioned2022-08-17T12:11:30Z
dc.date.available2022-08-17T12:11:30Z
dc.date.issued2022-01-24
dc.description.abstractThe purpose of this review is to present the current knowledge on the clinical use of several forms of cell therapy in hematological malignancies and the preclinical models available for their study. In the context of allogeneic hematopoietic stem cell transplants, mesenchymal stromal cells are pursued to help stem cell engraftment and expansion, and control graft versus host disease. We further summarize the status of promising forms of cellular immunotherapy including CAR T cell and CAR NK cell therapy aimed at eradicating the cells of origin of leukemia, i.e., leukemia stem cells. Updates on other forms of cellular immunotherapy, such as NK cells, CIK cells and CAR CIK cells, show encouraging results in AML. The considerations in available in vivo models for disease modelling and treatment efficacy prediction are discussed, with a particular focus on their strengths and weaknesses for the study of healthy and diseased hematopoietic stem cell reconstitution, graft versus host disease and immunotherapy. Despite current limitations, cell therapy is a rapidly evolving field that holds the promise of improved cure rates, soon. As a result, we may be witnessing the birth of the hematology of tomorrow. To further support its development, improved preclinical models including humanized microenvironments in mice are urgently needed.en_US
dc.identifier.citationArranz. The Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignancies. Cancers. 2022;14(3)en_US
dc.identifier.cristinIDFRIDAID 2025169
dc.identifier.doi10.3390/cancers14030580
dc.identifier.issn2072-6694
dc.identifier.urihttps://hdl.handle.net/10037/26247
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalCancers
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleThe Hematology of Tomorrow Is Here-Preclinical Models Are Not: Cell Therapy for Hematological Malignanciesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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