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dc.contributor.authorHansen, Solrunn
dc.date.accessioned2022-08-22T11:27:27Z
dc.date.available2022-08-22T11:27:27Z
dc.date.issued2011
dc.description.abstractPersistent toxic substances like organochlorines (OCs) and certain toxic metals have been or are extensively used, and can be globally distributed by long-range transport. The fetus and growing child are exposed via the placenta and breast milk and are vulnerable to their negative health effects. Concentrations measured in maternal blood or breast milk are thus potential indicators of risk for the next generation. Internal and external factors contribute to the maternal body burden of these toxicants including: age, parity, lactation, diet, past and current exposures, and the half-life of the contaminant in the body. Essential elements can modify the gastrointestinal absorption of toxic elements and thereby influence the negative impact of the latter. During the gestational and postpartum periods, remarkable physiological adaptions occur, and such changes have the potential to affect the maternal blood levels of persistent toxic substances and essential elements during these critical windows.<br> The main objectives of this thesis research were to: investigate maternal concentrations of OCs and non-essential (toxic) and essential elements in the context of a northern-southern latitude perspective; identify exposure predictors: and investigate the influence of physiological changes and related pregnancy adaptations during the gestational and postpartum periods.<br> The present work included pregnant and delivering women from two mother-and-child studies from Northern Norway (participant subsets of 50 and 211) and two communities in Southern Vietnam (total participants of 189), carried out respectively in 2007-09 and 2005. A suite of selected OC contaminants were analyzed in both study groups, and 5 toxic and 5 essential elements were additionally analyzed in the Northern Norwegian group. For the latter, changes in concentrations of all substances were investigated between three different collection periods: during the 21 trimester, and at 3 days and 6 weeks postpartum.<br> In the North Norwegian study, low maternal concentrations of both OCs and toxic elements, and normal levels of essential elements, were generally observed. The Vietnamese study demonstrated relatively high levels of p,p’-DDE and p,p’-DDT, among the highest globally speaking and possibly reflecting recent or current use. In contrast, the concentrations of PCBs were somewhat lower than those found among the Norwegian mothers.<br> For the OCs, age (positive) and parity (negative) were strong predictors, with the latter being strongly associated with lactation. For the elements, the exposure predictors were limited to mercury, namely age (positive) and parity (negative). Place of living was associated with the observed OC concentrations for the Vietnamese participants, and Sámi ethnicity for elements in the North Norwegian survey; both findings probably reflect different dietary patterns. Diet as a source was only assessed for the toxic and essential elements. Fish consumption was found to be a strong predictor for arsenic, mercury and selenium. Although not investigated in detail, fish and seafood intake can also be an important contributor to serum or plasma OCs levels. The lower PCB concentrations observed in Vietnam in combination with published suggestions of higher fish intake suggest the consumption of smaller, younger, and lean fish species in combination with low environmental deposition by long-range transport and minor local sources.<br> It is concluded that precaution (including dietary advice) is still relevant and important. In Vietnam, there is also a need to make pesticide-use restrictions more effective by providing the public with information on their possible health effects.<br> The most important findings are probably the patterns revealed for the concentrations of OCs and the non-essential (toxic) and essential elements as they appeared to be driven by the physiological adaptations during pregnancy. The wet-weight concentrations of the lipid soluble OCs followed the changes in lipid profiles that peaked at birth. In addition to paralleling metabolic, hematological and physiological changes during the gestational and postpartum periods, the concentrations of the elements also reflected their biochemistry and their accumulation preferences within the whole-blood compartment and breast milk. Our systematic approach and findings give a new understanding of the changing concentrations of toxicants and essential elements during pregnancy and have implications for the optimum monitoring time.en_US
dc.identifier.alma991147705304702201
dc.identifier.issn0801-017x
dc.identifier.urihttps://hdl.handle.net/10037/26318
dc.language.isoengen_US
dc.publisherUniversitetet i Tromsøen_US
dc.publisherUniversity of Tromsøen_US
dc.relation.ispartofseriesISM skriftserie Nr. 119, 2011en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2011 The Author(s)en_US
dc.subjectEnvironmental Pollutantsen_US
dc.subjectChlorine Compoundsen_US
dc.subjectPregnancyen_US
dc.subjectPostpartum Perioden_US
dc.subjectVietnamen_US
dc.subjectNord-Norgeen_US
dc.titleMaternal concentrations, predictors and change in profiles of organochlorines, toxic and essential elements during pregnancy and postpartum : the Vietnamese mother-and-child study and the Northern Norwegian mother-and-child studyen_US
dc.typeDoctoral thesisen_US
dc.typeDoktorgradsavhandlingen_US


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