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dc.contributor.authorMora, Dana Catalina
dc.contributor.authorOvervåg, Grete
dc.contributor.authorJong, Miek
dc.contributor.authorKristoffersen, Agnete Egilsdatter
dc.contributor.authorStavleu, Debbie C.
dc.contributor.authorLiu, J Ping
dc.contributor.authorStub, Trine
dc.date.accessioned2022-08-25T12:34:22Z
dc.date.available2022-08-25T12:34:22Z
dc.date.issued2022-04-02
dc.description.abstractBackground - Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and effect of CAM modalities to treat adverse effects of conventional cancer treatment among children and young adults.<p> <p>Methods - Six scientific research databases were used to identify randomized controlled trials (RCTs) from 1990 to September 2020. Included studies investigated the use of CAM to treat cancer treatment related adverse effects in children and young adults compared to controls.<p> <p>Results - Twenty RCTs comprising 1,069 participants were included in this review. The included studies investigated acupuncture, mind–body therapies, supplements, and vitamins for chemotherapy-induced nausea and vomiting (CINV), oral mucositis, and anxiety among children and young adults who underwent conventional cancer treatment. Seven studies (315 participants) were included in the meta-analysis. The overall effect of CAM (including acupuncture and hypnosis only) on chemotherapy-induced nausea and/or vomiting and controls was statistically significant with a standard mean difference of -0.54, 95% CI [-0.77, -0.31] I2 = 0% (p < 0.00001). There was a significant difference between acupuncture and controls (n = 5) for intensity and/or episodes of CINV with an SMD -0.59, 95% CI [-0.85, -0.33] (p < 0.00001). No significant difference was found between hypnosis and controls (n = 2) for severity or episodes of CINV with an SMD -0.41, 95% CI [-1.09, 0.27] I2 = 41% (p = 0.19).<p> <p>Conclusion - Current evidence from this meta-analysis of randomized controlled trials shows that CAM, including acupuncture and hypnosis only, is effective in reducing chemotherapy-induced nausea and vomiting in children and young adults. More rigorous trials and long-term effects should be investigated if acupuncture and hypnosis are to be recommended for clinical use.en_US
dc.identifier.citationMora DC, Overvåg G, Jong M, Kristoffersen AE, Stavleu, Liu JP, Stub T. Complementary and alternative medicine modalities used to treat adverse effects of anti‑cancer treatment among children and young adults: a systematic review and meta‑analysis of randomized controlled trials. BMC Complementary Medicine and Therapies. 2022en_US
dc.identifier.cristinIDFRIDAID 2017718
dc.identifier.doi10.1186/s12906-022-03537-w
dc.identifier.issn2662-7671
dc.identifier.urihttps://hdl.handle.net/10037/26425
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.ispartofMora, D.C. (2023). Complementary and alternative medicine use for supportive care in childhood cancer - Prevalence of use, effectiveness, safety and clinical practice. (Doctoral thesis). <a href=https://hdl.handle.net/10037/30620>https://hdl.handle.net/10037/30620</a>
dc.relation.journalBMC Complementary Medicine and Therapies
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.titleComplementary and alternative medicine modalities used to treat adverse effects of anti‑cancer treatment among children and young adults: a systematic review and meta‑analysis of randomized controlled trialsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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