Show simple item record

dc.contributor.authorClaeys, Liesel
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorBiessy, Carine
dc.contributor.authorCasagrande, Corinne
dc.contributor.authorNicolas, Genevieve
dc.contributor.authorKorenjak, Michael
dc.contributor.authorFervers, Beatrice
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorLuján-Barroso, Leila
dc.contributor.authorCastilla, Jesús
dc.contributor.authorLjungberg, Börje
dc.contributor.authorRodriguez-Barranco, Miguel
dc.contributor.authorEricson, Ulrika
dc.contributor.authorSantiuste, Carmen
dc.contributor.authorCatalano, Alberto
dc.contributor.authorOvervad, Kim
dc.contributor.authorBrustad, Magritt
dc.contributor.authorGunter, Marc J.
dc.contributor.authorZavadil, Jiri
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorHuybrechts, Inge
dc.date.accessioned2022-11-14T12:27:55Z
dc.date.available2022-11-14T12:27:55Z
dc.date.issued2022-08-30
dc.description.abstractBackground: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox’s proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day. Results: Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. Conclusions: These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty.en_US
dc.identifier.citationClaeys, De Saeger, Scelo, Biessy, Casagrande, Nicolas, Korenjak, Fervers, Heath, Krogh, Luján-Barroso, Castilla, Ljungberg, Rodriguez-Barranco, Ericson, Santiuste, Catalano, Overvad, Brustad, Gunter, Zavadil, De Boevre, Huybrechts. Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. Nutrients. 2022;14(17)en_US
dc.identifier.cristinIDFRIDAID 2056341
dc.identifier.doi10.3390/nu14173581
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/10037/27359
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalNutrients
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)