dc.contributor.author | Nimptsch, Katharina | |
dc.contributor.author | Aleksandrova, Krasimira | |
dc.contributor.author | Fedirko, Veronika | |
dc.contributor.author | Jenab, Mazda | |
dc.contributor.author | Gunter, Marc J. | |
dc.contributor.author | Siersema, Peter D. | |
dc.contributor.author | Wu, Kana | |
dc.contributor.author | Katzke, Verena | |
dc.contributor.author | Kaaks, Rudolf | |
dc.contributor.author | Panico, Salvatore | |
dc.contributor.author | Palli, Domenico | |
dc.contributor.author | May, Anne M | |
dc.contributor.author | Sieri, Sabina | |
dc.contributor.author | Bueno-de-Mesquita, Bas | |
dc.contributor.author | Olsen, Karina Standahl | |
dc.contributor.author | Sánchez, Maria-Jose | |
dc.contributor.author | Perez-Cornago, Aurora | |
dc.contributor.author | Olsen, Anja | |
dc.contributor.author | Tjønneland, Anne | |
dc.contributor.author | Bonet, Catalina Bonet | |
dc.contributor.author | Dahm, Christina C. | |
dc.contributor.author | Chirlaque, María-Dolores | |
dc.contributor.author | Fiano, Valentina | |
dc.contributor.author | Tumino, Rosario | |
dc.contributor.author | Gurrea, Aurelio Barricarte | |
dc.contributor.author | Boutron-Ruault, Marie-Christine | |
dc.contributor.author | Menegaux, Florence | |
dc.contributor.author | Severi, Gianluca | |
dc.contributor.author | van Guelpen, Bethany | |
dc.contributor.author | Lee, Young-Ae | |
dc.contributor.author | Pischon, Tobias | |
dc.date.accessioned | 2022-11-16T13:08:20Z | |
dc.date.available | 2022-11-16T13:08:20Z | |
dc.date.issued | 2022-06-24 | |
dc.description.abstract | <b><p>Background</b>
The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.
<b><p>Methods</b>
We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.
<b><p>Results</b>
During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively).
<b><p>Conclusions</b>
The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention. | en_US |
dc.identifier.citation | Nimptsch, Aleksandrova, Fedirko, Jenab, Gunter, Siersema, Wu, Katzke, Kaaks, Panico, Palli, May, Sieri, Bueno-de-Mesquita, Olsen, Sánchez, Perez-Cornago, Olsen, Tjønneland, Bonet, Dahm, Chirlaque, Fiano, Tumino, Gurrea, Boutron-Ruault, Menegaux, Severi, van Guelpen, Lee, Pischon. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations. BMC Cancer. 2022;22(1) | en_US |
dc.identifier.cristinID | FRIDAID 2054272 | |
dc.identifier.doi | 10.1186/s12885-022-09778-9 | |
dc.identifier.issn | 1471-2407 | |
dc.identifier.uri | https://hdl.handle.net/10037/27389 | |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.relation.journal | BMC Cancer | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |