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dc.contributor.authorHeather, Lisa C.
dc.contributor.authorHafstad, Anne Dragøy
dc.contributor.authorHalade, Ganesh V.
dc.contributor.authorHarmancey, Romain
dc.contributor.authorMellor, Kimberley M.
dc.contributor.authorMishra, Paras K.
dc.contributor.authorMulvihill, Erin E.
dc.contributor.authorNabben, Miranda
dc.contributor.authorNakamura, Michinari
dc.contributor.authorRider, Oliver J.
dc.contributor.authorRuiz, Matthieu
dc.contributor.authorWende, Adam R.
dc.contributor.authorUssher, John R.
dc.date.accessioned2022-11-24T09:14:44Z
dc.date.available2022-11-24T09:14:44Z
dc.date.issued2022-07-08
dc.description.abstractDiabetes is a major risk factor for cardiovascular diseases, including diabetic cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular disease represents the number one cause of death in people with diabetes, there has been a major emphasis on understanding the mechanisms by which diabetes promotes cardiovascular disease, and how antidiabetic therapies impact diabetic heart disease. With a wide array of models to study diabetes (both type 1 and type 2), the field has made major progress in answering these questions. However, each model has its own inherent limitations. Therefore, the purpose of this guidelines document is to provide the field with information on which aspects of cardiovascular disease in the human diabetic population are most accurately reproduced by the available models. This review aims to emphasize the advantages and disadvantages of each model, and to highlight the practical challenges and technical considerations involved. We will review the preclinical animal models of diabetes (based on their method of induction), appraise models of diabetes-related atherosclerosis and heart failure, and discuss in vitro models of diabetic heart disease. These guidelines will allow researchers to select the appropriate model of diabetic heart disease, depending on the specific research question being addressed.en_US
dc.identifier.citationHeather, Hafstad, Halade, Harmancey, Mellor, Mishra, Mulvihill, Nabben, Nakamura, Rider, Ruiz, Wende, Ussher. Guidelines on models of diabetic heart disease. American Journal of Physiology. Heart and Circulatory Physiology. 2022;323(1):H176-H200en_US
dc.identifier.cristinIDFRIDAID 2043727
dc.identifier.doi10.1152/ajpheart.00058.2022
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539
dc.identifier.urihttps://hdl.handle.net/10037/27511
dc.language.isoengen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.journalAmerican Journal of Physiology. Heart and Circulatory Physiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleGuidelines on models of diabetic heart diseaseen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)