Level of the Lipid Markers ApoA1 and ApoB in a General Youth Population. The Tromsø Study, Fit Futures 1

Abstract

Low serum Apolipoprotein A1 (ApoA1) and high Apolipoprotein B (ApoB) are risk factors for the development of cardiovascular disease. Studies have found tracking of lipid and lipoprotein levels form childhood and youth, into adult life. In order to identify an unfavorable lipid profile in young ages, knowledge about the distribution of these biomarkers in the general population is a prerequisite. Thus, the main aim of the thesis is to establish the distribution and reference intervals of serum ApoA1, ApoB, and ApoB/A1 ratio in a general youth population in Norway. To our knowledge, there are no previous Norwegian data on this topic. Furthermore, we will investigate if there are any associations between serum ApoA1 and ApoB and sex, BMI and waist-hip ratio, diet, and lifestyle factors such as tobacco use, alcohol use, and level of physical activity.