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dc.contributor.authorAl-Zalabani, Abdulmohsen H.
dc.contributor.authorWesselius, Anke
dc.contributor.authorYi-Wen Yu, Evan
dc.contributor.authorvan den Brandt, Piet
dc.contributor.authorGrant, Eric J.
dc.contributor.authorWhite, Emily
dc.contributor.authorSkeie, Guri
dc.contributor.authorLiedberg, Fredrik
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorZeegers, Maurice P.
dc.date.accessioned2023-01-05T11:38:38Z
dc.date.available2023-01-05T11:38:38Z
dc.date.issued2022-04-09
dc.description.abstractBackground & aims: Tea has been shown to be associated with reduced risk of several diseases including cardiovascular diseases, stroke, metabolic syndrome, and obesity. However, the results on the relationship between tea consumption and bladder cancer are conflicting. This research aimed to assess the association between tea consumption and risk of bladder cancer using a pooled analysis of prospective cohort data. Methods: Individual data from 532,949 participants in 12 cohort studies, were pooled for analyses. Cox regression models stratified by study centre was used to estimate hazard ratios (HR) and corresponding 95% CIs. Fractional polynomial regression models were used to examine the doseeresponse relationship. Results: A higher level of tea consumption was associated with lower risk of bladder cancer incidence (compared with no tea consumption: HR ¼ 0.87, 95% C.I. ¼ 0.77e0.98 for low consumption; HR ¼ 0.86, 95% C.I. ¼ 0.77e0.96 for moderate consumption; HR ¼ 0.84, 95% C.I. ¼ 0.75e0.95 for high consumption). When stratified by sex and smoking status, this reduced risk was statistically significant among men and current and former smokers. In addition, doseeresponse analyses showed a lower bladder cancer risk with increment of 100 ml of tea consumption per day (HR-increment ¼ 0.97; 95% CI ¼ 0.96e0.98). A similar inverse association was found among males, current and former smokers while never smokers and females showed non-significant results, suggesting potential sex-dependent effect. Conclusions: Higher consumption of tea is associated with reduced risk of bladder cancer with potential interaction with sex and smoking status. Further studies are needed to clarify the mechanisms for a protective effect of tea (e.g. inhibition of the survival and proliferation of cancer cells and antiinflammatory mechanisms) and its interaction with smoking and sex.en_US
dc.identifier.citationAl-Zalabani, Wesselius, Yi-Wen Yu, van den Brandt, Grant, White, Skeie, Liedberg, Weiderpass, Zeegers. Tea consumption and risk of bladder cancer in the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) Study: Pooled analysis of 12 international cohort studies. Clinical Nutrition. 2022;41(5):1122-1130en_US
dc.identifier.cristinIDFRIDAID 2018668
dc.identifier.doi10.1016/j.clnu.2022.03.020
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.urihttps://hdl.handle.net/10037/28039
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalClinical Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleTea consumption and risk of bladder cancer in the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) Study: Pooled analysis of 12 international cohort studiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
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