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dc.contributor.authorJohnsen, Liv-Hege
dc.contributor.authorHerder, Marit
dc.contributor.authorVangberg, Torgil Riise
dc.contributor.authorKloster, Roar
dc.contributor.authorIngebrigtsen, Tor
dc.contributor.authorIsaksen, Jørgen Gjernes
dc.contributor.authorMathiesen, Ellisiv B.
dc.date.accessioned2023-03-16T08:16:19Z
dc.date.available2023-03-16T08:16:19Z
dc.date.issued2022-06-10
dc.description.abstractBackground - Management of incidental unruptured intracranial aneurysms (UIAs) remains challenging and depends on their risk of rupture, estimated from the assumed prevalence of aneurysms and the incidence of aneurysmal subarachnoid haemorrhage. Reported prevalence varies, and consistent criteria for definition of UIAs are lacking. We aimed to study the prevalence of UIAs in a general population according to different definitions of aneurysm.<p> <p>Methods - Cross-sectional population-based study using 3-dimensional time-of-flight 3 Tesla MR angiography to identify size, type and location of UIAs in 1862 adults aged 40–84 years. Size was measured as the maximal distance between any two points in the aneurysm sac. Prevalence was estimated for different diameter cutoffs (≥1, 2 and 3 mm) with and without inclusion of extradural aneurysms.<p> <p>Results - The overall prevalence of intradural saccular aneurysms ≥2 mm was 6.6% (95% CI 5.4% to 7.6%), 7.5% (95% CI 5.9% to 9.2%) in women and 5.5% (95% CI 4.1% to 7.2%) in men. Depending on the definition of an aneurysm, the overall prevalence ranged from 3.8% (95% CI 3.0% to 4.8%) for intradural aneurysms ≥3 mm to 8.3% (95% CI 7.1% to 9.7%) when both intradural and extradural aneurysms ≥1 mm were included.<p> <p>Conclusion - Prevalence in this study was higher than previously observed in other Western populations and was substantially influenced by definitions according to size and extradural or intradural location. The high prevalence of UIAs sized <5 mm may suggest lower rupture risk than previously estimated. Consensus on more robust and consistent radiological definitions of UIAs is warranted.en_US
dc.identifier.citationJohnsen, Herder, Vangberg, Kloster, Ingebrigtsen, Isaksen, Mathiesen. Prevalence of unruptured intracranial aneurysms: impact of different definitions-the Tromsø Study. Journal of Neurology, Neurosurgery and Psychiatry. 2022;93(8):902-907en_US
dc.identifier.cristinIDFRIDAID 2060793
dc.identifier.doi10.1136/jnnp-2022-329270
dc.identifier.issn0022-3050
dc.identifier.issn1468-330X
dc.identifier.urihttps://hdl.handle.net/10037/28767
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofJohnsen, L.H. (2024). Intracranial artery disease in the general population. (Doctoral thesis). <a href=https://hdl.handle.net/10037/33718>https://hdl.handle.net/10037/33718</a>
dc.relation.journalJournal of Neurology, Neurosurgery and Psychiatry
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2022 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePrevalence of unruptured intracranial aneurysms: impact of different definitions-the Tromsø Studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
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