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dc.contributor.authorSahakyan, Mushegh
dc.contributor.authorBrudvik, Kristoffer Watten
dc.contributor.authorAngelsen, Jon-Helge
dc.contributor.authorDille-Amdam, Rachel G.
dc.contributor.authorSandvik, Oddvar Mathias
dc.contributor.authorEdwin, Bjørn von Gohren
dc.contributor.authorNymo, Linn Såve
dc.contributor.authorLassen, Kristoffer
dc.date.accessioned2023-08-09T09:09:00Z
dc.date.available2023-08-09T09:09:00Z
dc.date.issued2023-05-04
dc.description.abstractBackground Preoperative inflammatory markers were shown to be associated with prognosis following surgery for hepato-pancreato-biliary cancer. Yet little evidence exists about their role in patients with colorectal liver metastases (CRLM). This study aimed to examine the association between selected preoperative inflammatory markers and outcomes of liver resection for CRLM.<p> <p>Methods Data from the Norwegian National Registry for Gastrointestinal Surgery (NORGAST) was used to capture all liver resections performed in Norway within the study period (November 2015–April 2021). Preoperative inflammatory markers were Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS) and C-reactive protein to albumin ratio (CAR). The impact of these on postoperative outcomes, as well as on survival were studied. <p>Results Liver resections for CRLM were performed in 1442 patients. Preoperative GPS C 1 and mGPS C 1 were present in 170 (11.8%) and 147 (10.2%) patients, respectively. Both were associated with severe complications but became non-significant in the multivariable model. GPS, mGPS, CAR were significant predictors for overall survival in the univariable analysis, but only CAR remained such in the multivariable model. When stratified by the type of surgical approach, CAR was a significant predictor for survival after open but not laparoscopic liver resections. <p>Conclusions GPS, mGPS and CAR have no impact on severe complications after liver resection for CRLM. CAR outperforms GPS and mGPS in predicting overall survival in these patients, especially following open resections. The prognostic significance of CAR in CRLM should be tested against other clinical and pathology parameters relevant for prognosis.en_US
dc.identifier.citationSahakyan, Brudvik, Angelsen, Dille-Amdam, Sandvik, Edwin, Nymo, Lassen. Preoperative Inflammatory Markers in Liver Resection for Colorectal Liver Metastases: A National Registry-Based Study. World Journal of Surgery. 2023en_US
dc.identifier.cristinIDFRIDAID 2152865
dc.identifier.doi10.1007/s00268-023-07035-z
dc.identifier.issn0364-2313
dc.identifier.issn1432-2323
dc.identifier.urihttps://hdl.handle.net/10037/29801
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalWorld Journal of Surgery
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePreoperative Inflammatory Markers in Liver Resection for Colorectal Liver Metastases: A National Registry-Based Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)