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dc.contributor.authorBoot, Iris W.A.
dc.contributor.authorWesselius, Anke
dc.contributor.authorYu, Evan Y.W.
dc.contributor.authorWhite, Emily
dc.contributor.authorBrustad, Magritt
dc.contributor.authorMarques, Chloé
dc.contributor.authorLjungberg, Borje
dc.contributor.authorZeegers, Maurice P.
dc.date.accessioned2023-08-10T08:49:54Z
dc.date.available2023-08-10T08:49:54Z
dc.date.issued2023-05-22
dc.description.abstractBackground & aims - Diet may play an essential role in the aetiology of bladder cancer (BC). Vitamin D is involved in various biological functions which have the potential to prevent BC development. Besides, vitamin D also influences the uptake of calcium and phosphorus, thereby possibly indirectly influencing the risk of BC. The aim of the present study was to investigate the relation between vitamin D intake and BC risk.<p> <p>Methods - Individual dietary data were pooled from ten cohort studies. Food item intake was converted to daily intakes of vitamin D, calcium and phosphorus. Pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs) were obtained using Cox-regression models. Analyses were adjusted for gender, age and smoking status (Model 1), and additionally for the food groups fruit, vegetables and meat (Model 2). Dose–response relationships (Model 1) were examined using a nonparametric test for trend.<p> <p>Results - In total, 1994 cases and 518,002 non-cases were included in the analyses. The present study showed no significant associations between individual nutrient intake and BC risk. A significant decreased BC risk was observed for high vitamin D intake with moderate calcium and low phosphorus intake (Model 2: HRhigh vitD, mod Ca, low P: 0.77, 95% CI: 0.59–1.00). No significant dose–response analyses were observed.<p> <p>Conclusion - The present study showed a decreased BC risk for high dietary vitamin D intake in combination with low calcium intake and moderate phosphorus intake. The study highlights the importance of examining the effect of a nutrient in combination with complementary nutrients for risk assessment. Future research should focus on nutrients in a wider context and in nutritional patterns.en_US
dc.identifier.citationBoot, Wesselius, Yu, White, Brustad, Marques, Ljungberg, Zeegers. Dietary vitamin D intake and the bladder cancer risk: A pooled analysis of prospective cohort studies. Clinical Nutrition. 2023en_US
dc.identifier.cristinIDFRIDAID 2162078
dc.identifier.doi10.1016/j.clnu.2023.05.010
dc.identifier.issn0261-5614
dc.identifier.issn1532-1983
dc.identifier.urihttps://hdl.handle.net/10037/29833
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalClinical Nutrition
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleDietary vitamin D intake and the bladder cancer risk: A pooled analysis of prospective cohort studiesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)