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dc.contributor.authorClasen, Joanna L.
dc.contributor.authorMabunda, Rita
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKatzke, Verena
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorBirukov, Anna
dc.contributor.authorTagliabue, Giovanna
dc.contributor.authorChiodini, Paolo
dc.contributor.authorTumino, Rosario
dc.contributor.authorMilani, Lorenzo
dc.contributor.authorBraaten, Tonje Bjørndal
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorLukic, Marko
dc.contributor.authorLuján-Barroso, Leila
dc.contributor.authorRodriguez-Barranco, Miguel
dc.contributor.authorChirlaque, María-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorAmiano, Pilar
dc.contributor.authorManjer, Jonas
dc.contributor.authorHuss, Linnea
dc.contributor.authorLjungberg, Börje
dc.contributor.authorTravis, Ruth
dc.contributor.authorSmith-Byrne, Karl
dc.contributor.authorGunter, Marc
dc.contributor.authorJohansson, Matthias
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorRiboli, Elio
dc.contributor.authorCross, Amanda J.
dc.contributor.authorMuller, David C.
dc.date.accessioned2023-08-10T11:05:12Z
dc.date.available2023-08-10T11:05:12Z
dc.date.issued2023-06-03
dc.description.abstractBackground - Renal cell carcinoma (RCC) is twice as common among men compared with women, and hormonal factors have been suggested to partially explain this difference. There is currently little evidence on the roles of reproductive and hormonal risk factors in RCC aetiology.<p> <p>Materials & Methods - We investigated associations of age at menarche and age at menopause, pregnancy-related factors, hysterectomy and ovariectomy and exogenous hormone use with RCC risk among 298,042 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.<p> <p>Results - During 15 years of follow-up, 438 RCC cases were identified. Parous women had higher rates of RCC compared with nulliparous women (HR = 1.71, 95% CI 1.18, 2.46), and women who were older at age of first pregnancy had lower rates of RCC (30 years + vs. <20 years HR = 0.53, 95% CI 0.34, 0.82). Additionally, we identified a positive association for hysterectomy (HR = 1.43 95% CI 1.09, 1.86) and bilateral ovariectomy (HR = 1.67, 95% CI 1.13, 2.47), but not unilateral ovariectomy (HR = 0.99, 95% CI 0.61, 1.62) with RCC risk. No clear associations were found for age at menarche, age at menopause or exogenous hormone use.<p> <p>Conclusion - Our results suggest that parity and reproductive organ surgeries may play a role in RCC aetiology.en_US
dc.identifier.citationClasen, Mabunda, Heath, Kaaks, Katzke, Schulze, Birukov, Tagliabue, Chiodini, Tumino, Milani, Braaten, Gram, Lukic, Luján-Barroso, Rodriguez-Barranco, Chirlaque, Ardanaz, Amiano, Manjer, Huss, Ljungberg, Travis, Smith-Byrne, Gunter, Johansson, Rinaldi, Weiderpass, Riboli, Cross, Muller. Reproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutrition. Cancer Medicine. 2023en_US
dc.identifier.cristinIDFRIDAID 2159086
dc.identifier.doi10.1002/cam4.6207
dc.identifier.issn2045-7634
dc.identifier.urihttps://hdl.handle.net/10037/29853
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalCancer Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleReproductive and hormonal factors and risk of renal cell carcinoma among women in the European Prospective Investigation into Cancer and Nutritionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)