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dc.contributor.authorBörschel, Christin S.
dc.contributor.authorGeelhoed, Bastiaan
dc.contributor.authorNiiranen, Teemu
dc.contributor.authorCamen, Stephan
dc.contributor.authorDonati, Maria Benedetta
dc.contributor.authorHavulinna, Aki S.
dc.contributor.authorGianfagna, Francesco
dc.contributor.authorPalosaari, Tarja
dc.contributor.authorJousilahti, Pekka
dc.contributor.authorKontto, Jukka
dc.contributor.authorVartiainen, Erkki
dc.contributor.authorOjeda, Francisco M.
dc.contributor.authorden Ruijter, Hester M.
dc.contributor.authorCostanzo, Simona
dc.contributor.authorde Gaetano, Giovanni
dc.contributor.authorDi Castelnuovo, Augusto
dc.contributor.authorLinneberg, Allan
dc.contributor.authorVishram-Nielsen, Julie K.
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorJørgensen, Torben
dc.contributor.authorKuulasmaa, Kari
dc.contributor.authorBlankenberg, Stefan
dc.contributor.authorIacoviello, Licia
dc.contributor.authorZeller, Tanja
dc.contributor.authorSöderberg, Stefan
dc.contributor.authorSalomaa, Veikko
dc.contributor.authorSchnabel, Renate B.
dc.date.accessioned2023-08-14T11:42:02Z
dc.date.available2023-08-14T11:42:02Z
dc.date.issued2023-01-05
dc.description.abstractAims - Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.<p> <p>Methods - We investigated the predictive ability of hsTnI for incident AF in 45,298 participants (median age 51.4 years, 45.0% men) across European community cohorts in comparison to CVRF and established biomarkers (C-reactive protein, N-terminal pro B-type natriuretic peptide).<p> <p>Results - During a median follow-up of 7.7 years, 1734 (3.8%) participants developed AF. Those in the highest hsTnI quarter (≥4.2 ng/L) had a 3.91-fold (95% confidence interval (CI) 3.30, 4.63; p < .01) risk for developing AF compared to the lowest quarter (<1.4 ng/L). In multivariable-adjusted Cox proportional hazards models a statistically significant association was seen between hsTnI and AF (hazard ratio (HR) per 1 standard deviation (SD) increase in log10(hsTnI) 1.08; 95% CI 1.01, 1.16; p = .03). Inclusion of hsTnI did improve model discrimination (C-index CVRF 0.811 vs. C-index CVRF and hsTnI 0.813; p < .01). Higher hsTnI concentrations were associated with heart failure (HR per SD 1.37; 95% CI 1.12, 1.68; p < .01) and overall mortality (HR per SD 1.24; 95% CI 1.09, 1.41; p < .01).<p> <p>Conclusion - hsTnI as a biomarker of myocardial injury does not improve prediction of AF incidence beyond classical CVRF and NT-proBNP. However, it is associated with the AF-related disease heart failure and mortality likely reflecting underlying subclinical cardiovascular impairment.en_US
dc.identifier.citationBörschel, Geelhoed, Niiranen, Camen, Donati, Havulinna, Gianfagna, Palosaari, Jousilahti, Kontto, Vartiainen, Ojeda, den Ruijter, Costanzo, de Gaetano, Di Castelnuovo, Linneberg, Vishram-Nielsen, Løchen, Koenig, Jørgensen, Kuulasmaa, Blankenberg, Iacoviello, Zeller, Söderberg, Salomaa, Schnabel. Risk prediction of atrial fibrillation and its complications in the community using hs troponin I. European Journal of Clinical Investigation. 2023;53(5)en_US
dc.identifier.cristinIDFRIDAID 2140787
dc.identifier.doi10.1111/eci.13950
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.urihttps://hdl.handle.net/10037/29903
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalEuropean Journal of Clinical Investigation
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleRisk prediction of atrial fibrillation and its complications in the community using hs troponin Ien_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
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