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dc.contributor.authorFenton, Christopher Graham
dc.contributor.authorRay, Mithlesh Kumar
dc.contributor.authorMeng, Wei
dc.contributor.authorPaulssen, Ruth H
dc.date.accessioned2023-08-15T07:55:55Z
dc.date.available2023-08-15T07:55:55Z
dc.date.issued2023-06-22
dc.description.abstractLong non-coding RNAs (lncRNAs) have been shown to play a role in the pathogenesis of ulcerative colitis (UC). Although epigenetic processes such as DNA methylation and lncRNA expression are well studied in UC, the importance of the interplay between the two processes has not yet been fully explored. It is, therefore, believed that interactions between environmental factors and epigenetics contribute to disease development. Mucosal biopsies from 11 treatment-naïve UC patients and 13 normal controls were used in this study. From each individual sample, both whole-genome bisulfite sequencing data (WGBS) and lncRNA expression data were analyzed. Correlation analysis between lncRNA expression and upstream differentially methylated regions (DMRs) was used to identify lncRNAs that might be regulated by DMRs. Furthermore, proximal protein-coding genes associated with DMR-regulated lncRNAs were identified by correlating their expression. The study identified UC-associated lncRNAs such as MIR4435-2HG, ZFAS1, IL6-AS1, and Pvt1, which may be regulated by DMRs. Several genes that are involved in inflammatory immune responses were found downstream of DMR-regulated lncRNAs, including SERPINB1, CCL18, and SLC15A4. The interplay between lncRNA expression regulated by DNA methylation in UC might improve our understanding of UC pathogenesis.en_US
dc.identifier.citationFenton CG, Ray M, Meng W, Paulssen RH. Methylation-regulated long non-coding RNA expression in ulcerative colitis. International Journal of Molecular Sciences. 2023;24en_US
dc.identifier.cristinIDFRIDAID 2160718
dc.identifier.doi10.3390/ijms241310500
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/29934
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.ispartofRay, M.R. (2024). Long non-coding RNAs in ulcerative colitis. (Doctoral thesis). <a href=https://hdl.handle.net/10037/33648>https://hdl.handle.net/10037/33648</a>.
dc.relation.journalInternational Journal of Molecular Sciences
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMethylation-regulated long non-coding RNA expression in ulcerative colitisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)