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dc.contributor.authorZhao, Fangfang
dc.contributor.authorChen, Luying
dc.contributor.authorJiang, Yuerong
dc.contributor.authorGuo, Yaxin
dc.contributor.authorLu, Lijie
dc.contributor.authorLu, Chunli
dc.contributor.authorXue, Xue
dc.contributor.authorLiu, Xuehan
dc.contributor.authorJin, Xinyan
dc.contributor.authorLiu, Jianping
dc.contributor.authorChen, Keji
dc.date.accessioned2023-08-18T10:07:04Z
dc.date.available2023-08-18T10:07:04Z
dc.date.issued2023-03-22
dc.description.abstractThis research was to summarize the comparative efficacy and safety of red yeast rice (RYR) preparations and analyze the treatment ranking of lipid-lowering agents including RYR. Thirty-one systematic reviews (SRs) involving 165 randomized trials with 14,987 dyslipidemia participants were included. All the SRs showed a high overall risk of bias. A Bayesian network meta-analysis was performed. Only five trials reported major adverse cardiovascular events (MACE) and three trials reported lipoprotein(a)[Lp(a)]. Compared to placebo or other lipid-lowering drugs, RYR preparations showed some regulating action on lipids and glucose metabolism, with fewer side effects (P < 0.05). Compared to placebo, RYR showed a tendency to reduce Lp(a) levels. Lipid-lowering agents ranked differently in each outcome. High-quality evidence showed RYR (Zhibituo) lowered total cholesterol and triglyceride levels more than placebo. This study reveals the efficacy and safety ranking of RYR preparations for dyslipidemia, and it’s recommended that future trials should focus on MACE and Lp(a).en_US
dc.identifier.citationZhao, Chen, Jiang, Guo, Lu, Lu, Xue, Liu, Jin, Liu, Chen. Red yeast rice preparations for dyslipidemia: An overview of systematic reviews and network meta-analysis. Journal of Functional Foods. 2023;104en_US
dc.identifier.cristinIDFRIDAID 2158292
dc.identifier.doi10.1016/j.jff.2023.105508
dc.identifier.issn1756-4646
dc.identifier.issn2214-9414
dc.identifier.urihttps://hdl.handle.net/10037/30073
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of Functional Foods
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleRed yeast rice preparations for dyslipidemia: An overview of systematic reviews and network meta-analysisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)