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dc.contributor.authorAhimbisibwe, Ashley
dc.contributor.authorValberg, Morten
dc.contributor.authorGreen, Adele C.
dc.contributor.authorGhiasvand, Reza
dc.contributor.authorRüegg, Corina Silvia
dc.contributor.authorRimal, Raju
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSandanger, Torkjel M
dc.contributor.authorRobsahm, Trude Eid
dc.contributor.authorVeierød, Marit Bragelien
dc.date.accessioned2023-08-18T11:15:50Z
dc.date.available2023-08-18T11:15:50Z
dc.date.issued2023-04-04
dc.description.abstractLittle is known about if and how nevi and pigmentation are associated with melanoma-specific mortality. However, increased melanoma awareness in people with lighter pigmentation and many nevi may result in earlier diagnosis of thinner less-lethal tumors. The aim of this study was to investigate associations between nevus count (asymmetrical > 5 mm and small symmetrical), pigmentary characteristics (hair colour, eye colour, skin colour, freckling, pigmentary score), and melanoma-specific mortality in subjects with melanomas > 1 mm. Data from the Norwegian Women and Cancer cohort, established in 1991, with complete follow-up of melanoma patients until 2018 through the Cancer Registry of Norway, were used to estimate hazard ratios with 95% confidence intervals for the associations between nevus count, pigmentary characteristics, and melanoma-specific mortality, stratified by tumor thickness using Cox regression. Estimated hazard ratios consistently indicated a higher risk of melanoma death for those with darker vs lighter pigmentary characteristics in patients with tumors > 1.0–2.0 mm and > 2.0 mm thick (e.g. pigmentary score hazard ratio 1.25, 95% confidence interval (0.74–2.13)). Among women with melanomas >1.0 mm thick, lighter pigmentation and asymmetrical nevi may be associated with lower melanoma-specific mortality, suggesting that factors that increase the risk of melanoma may also be associated with decreased risk of death from melanoma.en_US
dc.identifier.citationAhimbisibwe, Valberg, Green, Ghiasvand, Rüegg, Rimal, Weiderpass, Sandanger, Robsahm, Veierød. Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick. Acta Dermato-Venereologica. 2023;103:adv4403en_US
dc.identifier.cristinIDFRIDAID 2143495
dc.identifier.doi10.2340/actadv.v103.4403
dc.identifier.issn0001-5555
dc.identifier.issn1651-2057
dc.identifier.urihttps://hdl.handle.net/10037/30088
dc.language.isoengen_US
dc.publisherMedical Journals Swedenen_US
dc.relation.journalActa Dermato-Venereologica
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleNevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thicken_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)