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dc.contributor.authorSahakyan, Mushegh
dc.contributor.authorKleive, Dyre
dc.contributor.authorDille-Amdam, Rachel G.
dc.contributor.authorKjeseth, Trond
dc.contributor.authorWaardal, Kim
dc.contributor.authorEdwin, Bjørn von Gohren
dc.contributor.authorNymo, Linn Såve
dc.contributor.authorLassen, Kristoffer
dc.date.accessioned2023-08-29T11:45:26Z
dc.date.available2023-08-29T11:45:26Z
dc.date.issued2023-06-15
dc.description.abstractBackground and purpose Preoperative infammatory markers, such as Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio, were shown to be associated with prognosis in patients undergoing pancreatectomy for cancer. However, little is known about their predictive role in a Western population.<p> <p>Methods The Norwegian National Registry for Gastrointestinal Surgery (NORGAST) was used to capture all pancreatectomies performed within the study period (November 2015—April 2021). The association between the preoperative infammatory markers and postoperative outcomes was studied. Their impact on survival was examined in patients operated for pancreatic ductal adenocarcinoma. <p>Results A total of 1554 patients underwent pancreatectomy in this period. Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio were associated with severe complications (Accordion grade≥III) in the univariable but not in the multivariable analysis. C-reactive protein to albumin ratio, but not Glasgow prognostic score and modifed Glasgow prognostic score, was linked to survival following pancreatectomy for ductal adenocarcinoma. In the multivariable model, age, neoadjuvant chemotherapy, ECOG score, C-reactive protein to albumin ratio and total pancreatectomy correlated with survival. Also, preoperative C-reactive protein to albumin ratio was signifcantly associated with survival after pancreatoduodenectomy. <p>Conclusions Preoperative Glasgow prognostic score, modifed Glasgow prognostic score and C-reactive protein to albumin ratio have no role in predicting the complications after pancreatectomy. C-reactive protein to albumin ratio is a signifcant predictor for survival in ductal adenocarcinoma, yet its clinical relevance should be explored in conjunction with the pathology parameters and adjuvant therapy.en_US
dc.identifier.citationSahakyan, Kleive, Dille-Amdam, Kjeseth, Waardal, Edwin, Nymo, Lassen. The Role of Preoperative Inflammatory Markers in Pancreatectomy: a Norwegian Nationwide Cohort Study. Journal of Gastrointestinal Surgery. 2023en_US
dc.identifier.cristinIDFRIDAID 2159321
dc.identifier.doi10.1007/s11605-023-05726-5
dc.identifier.issn1091-255X
dc.identifier.issn1873-4626
dc.identifier.urihttps://hdl.handle.net/10037/30511
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalJournal of Gastrointestinal Surgery
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleThe Role of Preoperative Inflammatory Markers in Pancreatectomy: a Norwegian Nationwide Cohort Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)