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dc.contributor.authorNieder, Carsten
dc.contributor.authorMannsåker, Bård
dc.contributor.authorDalhaug, Astrid
dc.date.accessioned2023-09-01T12:22:26Z
dc.date.available2023-09-01T12:22:26Z
dc.date.issued2023-02-14
dc.description.abstractBackground: This study analyzed the percent of remaining life (PRL) on treatment in patients irradiated for bone metastases. Bone metastases were treated together with other target volumes, if indicated, e.g. a 10-fraction treatment course that included brain and bone metastases. PRL was determined by calculating the time between start and finish of palliative radiotherapy (minimum 1 day in case of a single-fraction regimen) and dividing it by overall survival in days from start of radiotherapy. <p> <p>Materials and methods: Different baseline parameters were assessed for association with dichotomized PRL (< 5% vs. ≥ 5%). The retrospective study included 219 patients (287 courses of palliative radiotherapy). After univariate analyses, multi-nominal logistic regression was employed. <p> <p>Results: PRL on treatment ranged from 1–23%. Single-fraction radiotherapy resulted in < 5% PRL on treatment in all cases. All courses with 10 fractions resulted in at least 5% PRL on treatment. Significant associations were found between various baseline parameters and PRL category. With fractionation included in the regression model, 3 parameters retained significant p-values: Karnofsky performance status (KPS), none-bone target volume and fractionation (all with p < 0.001). If analyzed without fractionation, none-bone target volume (p < 0.001), hemoglobin (p < 0.001), KPS (p = 0.01), lack of additional systemic treatment (p = 0.01), and hypercalcemia (p = 0.04) were significant. <p> <p>Conclusions: Fractionation is an easily modifiable factor with high impact on PRL. Patients with KPS < 70 and those treated for additional target types during the same course are at high risk of spending a larger proportion of their remaining life on treatment.en_US
dc.identifier.citationNieder, Mannsåker, Dalhaug. Percent of remaining life on palliative radiation treatment: solely a function of fractionation?. Reports of Practical Oncology and Radiotherapy. 2023;28(1):47-53
dc.identifier.cristinIDFRIDAID 2144218
dc.identifier.doi10.5603/RPOR.a2023.0013
dc.identifier.issn1507-1367
dc.identifier.issn2083-4640
dc.identifier.urihttps://hdl.handle.net/10037/30627
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalReports of Practical Oncology and Radiotherapy
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en_US
dc.titlePercent of remaining life on palliative radiation treatment: solely a function of fractionation?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)