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dc.contributor.authorOlsvik, Hallvard Lauritz
dc.contributor.authorJohansen, Terje
dc.date.accessioned2023-09-04T10:49:36Z
dc.date.available2023-09-04T10:49:36Z
dc.date.issued2023-02-08
dc.description.abstractProteins are structural and executing macromolecules essential for life in all biological systems. Insight into proteins structures is required for detailed mechanistic understanding of how they work and solve different tasks. The ability to predict three-dimensional (3D) protein structures from primary sequence information has therefore been an open research question for more than 50 years. The search for this holy grail of structural bioinformatics has recently led to development of AlphaFold2, an amazing artificial intelligence–based structure prediction tool, developed by scientists from Google DeepMind [1]. How does AlphaFold2 work? Very briefly, it searches sequence databases to find sequences similar to the input, produces a multiple sequence alignment, uses a neural network to extract information, and sends that information to a second neural network that calculates a 3D structure. This is done in an iterative manner. In this issue of PLOS Biology, Ibrahim and colleagues demonstrate how AlphaFold2 (AF2)-multimer can be used as an important and powerful new tool to successfully predict so-called LC3 interacting region (LIR) motifs (see below) in proteins involved in autophagy processes [2].en_US
dc.identifier.citationOlsvik, Johansen. AlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy research. PLoS Biology. 2023;21(2)
dc.identifier.cristinIDFRIDAID 2151086
dc.identifier.doi10.1371/journal.pbio.3002002
dc.identifier.issn1544-9173
dc.identifier.issn1545-7885
dc.identifier.urihttps://hdl.handle.net/10037/30671
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.journalPLoS Biology
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAlphaFold-multimer predicts ATG8 protein binding motifs crucial for autophagy researchen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)