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dc.contributor.authorNieder, Carsten
dc.contributor.authorAndratschke, Nicolaus H.
dc.contributor.authorGrosu, Anca L.
dc.date.accessioned2023-09-08T10:39:57Z
dc.date.available2023-09-08T10:39:57Z
dc.date.issued2023-08-08
dc.description.abstractBiologically younger, fully independent octogenarians are able to tolerate most oncological treatments. Increasing frailty results in decreasing eligibility for certain treatments, e.g., chemotherapy and surgery. Most brain metastases are not an isolated problem, but part of widespread cancer dissemination, often in combination with compromised performance status. Multidisciplinary assessment is key in this vulnerable patient population where age, frailty, comorbidity and even moderate additional deficits from brain metastases or their treatment may result in immobilization, hospitalization, need for nursing home care, termination of systemic anticancer treatment etc. Here, we provide examples of successful treatment (surgery, radiosurgery, systemic therapy) and best supportive care, and comment on the limitations of prognostic scores, which often were developed in all-comers rather than octogenarians. Despite selection bias in retrospective studies, survival after radiosurgery was more encouraging than after whole-brain radiotherapy. Prospective research with focus on octogenarians is warranted to optimize outcomes.en_US
dc.identifier.citationNieder, Andratschke, Grosu. How we treat octogenarians with brain metastases. Frontiers in Oncology. 2023;13:1-6en_US
dc.identifier.cristinIDFRIDAID 2171639
dc.identifier.doi10.3389/fonc.2023.1213122
dc.identifier.issn2234-943X
dc.identifier.urihttps://hdl.handle.net/10037/30828
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleHow we treat octogenarians with brain metastasesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)