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dc.contributor.authorBirgisdottir, Åsa birna
dc.contributor.authorJohansen, Terje
dc.date.accessioned2023-09-11T12:16:38Z
dc.date.available2023-09-11T12:16:38Z
dc.date.issued2020-05-22
dc.description.abstractAutophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation and recycling of intracellular and extracellular components, respectively. These pathways have a common endpoint at the lysosome, where their cargo is degraded. In addition, the two pathways intersect at different stages during vesicle formation, fusion and trafficking, and share parts of the molecular machinery. Accumulating evidence shows that autophagy is dependent upon endocytosis and vice versa. The emerging joint network of autophagy and endocytosis is of vital importance for cellular metabolism and signaling, and thus also highly relevant in disease settings. In this Review, we will discuss examples of how the autophagy machinery impacts on endocytosis and cell signaling, and highlight how endocytosis regulates the different steps in autophagy in mammalian cells. Finally, we will focus on the interplay of these pathways in the quality control of their common endpoint, the lysosome.en_US
dc.identifier.citationBirgisdottir, Johansen. Autophagy and endocytosis – interconnections and interdependencies. Journal of Cell Science. 2020;133(10)en_US
dc.identifier.cristinIDFRIDAID 1849365
dc.identifier.doi10.1242/jcs.228114
dc.identifier.issn0021-9533
dc.identifier.issn1477-9137
dc.identifier.urihttps://hdl.handle.net/10037/30912
dc.language.isoengen_US
dc.publisherThe Company of Biologistsen_US
dc.relation.journalJournal of Cell Science
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.titleAutophagy and endocytosis – interconnections and interdependenciesen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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