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dc.contributor.authorKarlberg, Anna Maria
dc.contributor.authorPedersen, Lars Kjelsberg
dc.contributor.authorVindstad, Benedikte Emilie
dc.contributor.authorSkjulsvik, Anne Jarstein
dc.contributor.authorJohansen, Håkon
dc.contributor.authorSolheim, Ole Skeidsvoll
dc.contributor.authorSkogen, Karoline
dc.contributor.authorKvistad, Kjell Arne
dc.contributor.authorBogsrud, Trond
dc.contributor.authorMyrmel, Kristin Smistad
dc.contributor.authorGiskeødegård, Guro F.
dc.contributor.authorIngebrigtsen, Tor
dc.contributor.authorBerntsen, Erik Magnus
dc.contributor.authorEikenes, Live
dc.date.accessioned2023-11-21T12:43:53Z
dc.date.available2023-11-21T12:43:53Z
dc.date.issued2023-09-30
dc.description.abstractPurpose - The primary aim was to evaluate whether anti-3-[<sup>18</sup>F]FACBC PET combined with conventional MRI correlated better with histomolecular diagnosis (reference standard) than MRI alone in glioma diagnostics. The ability of anti-3-[<sup>18</sup>F]FACBC to differentiate between molecular and histopathological entities in gliomas was also evaluated.<p> <p>Methods - In this prospective study, patients with suspected primary or recurrent gliomas were recruited from two sites in Norway and examined with PET/MRI prior to surgery. Anti-3-[<sup>18</sup>F]FACBC uptake (TBR<sub>peak</sub>) was compared to histomolecular features in 36 patients. PET results were then added to clinical MRI readings (performed by two neuroradiologists, blinded for histomolecular results and PET data) to assess the predicted tumor characteristics with and without PET.<p> <p>Results - Histomolecular analyses revealed two CNS WHO grade 1, nine grade 2, eight grade 3, and 17 grade 4 gliomas. All tumors were visible on MRI FLAIR. The sensitivity of contrast-enhanced MRI and anti-3-[<sup>18</sup>F]FACBC PET was 61% (95%CI [45, 77]) and 72% (95%CI [58, 87]), respectively, in the detection of gliomas. Median TBR<sub>peak</sub> was 7.1 (range: 1.4–19.2) for PET positive tumors. All CNS WHO grade 1 pilocytic astrocytomas/gangliogliomas, grade 3 oligodendrogliomas, and grade 4 glioblastomas/astrocytomas were PET positive, while 25% of grade 2–3 astrocytomas and 56% of grade 2–3 oligodendrogliomas were PET positive. Generally, TBR<sub>peak</sub> increased with malignancy grade for diffuse gliomas. A significant difference in PET uptake between CNS WHO grade 2 and 4 gliomas (p < 0.001) and between grade 3 and 4 gliomas (p = 0.002) was observed. Diffuse IDH wildtype gliomas had significantly higher TBR<sub>peak</sub> compared to IDH1/2 mutated gliomas (p < 0.001). Adding anti-3-[<sup>18</sup>F]FACBC PET to MRI improved the accuracy of predicted glioma grades, types, and IDH status, and yielded 13.9 and 16.7 percentage point improvement in the overall diagnoses for both readers, respectively.<p> <p>Conclusion - Anti-3-[<sup>18</sup>F]FACBC PET demonstrated high uptake in the majority of gliomas, especially in IDH wildtype gliomas, and improved the accuracy of preoperatively predicted glioma diagnoses.en_US
dc.identifier.citationKarlberg, Pedersen, Vindstad, Skjulsvik, Johansen, Solheim, Skogen, Kvistad, Bogsrud, Myrmel, Giskeødegård, Ingebrigtsen, Berntsen, Eikenes. Diagnostic accuracy of anti-3-[<sup>18</sup>F]-FACBC PET/MRI in gliomas. European Journal of Nuclear Medicine and Molecular Imaging. 2023
dc.identifier.cristinIDFRIDAID 2186345
dc.identifier.doi10.1007/s00259-023-06437-4
dc.identifier.issn1619-7070
dc.identifier.issn1619-7089
dc.identifier.urihttps://hdl.handle.net/10037/31843
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalEuropean Journal of Nuclear Medicine and Molecular Imaging
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleDiagnostic accuracy of anti-3-[<sup>18</sup>F]-FACBC PET/MRI in gliomasen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)