Institutt for klinisk medisin: Recent submissions
Now showing items 1021-1040 of 1800
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Cytokine profiling and post-transfusion haemoglobin increment in patients with haematological diseases
(Journal article; Tidsskriftartikkel, 2018-08-29)<p><i>Background and Objectives</i>: In a previous pilot study, we demonstrated significantly lower haemoglobin (Hb) increment after red‐blood‐cell (RBC) transfusions in febrile patients compared to patients without fever. The aim of this study was to examine associations between inflammatory mediators and post‐transfusion haemoglobin increment in patients with haematological diseases.</p> <p>< ... -
Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-16)<p><i>Background</i>: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation.</p> <p><i>Methods</i>: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%).</p> <p><i>Results</i>: Regarding practices around ... -
Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy ... -
Long-Term Incidence of Venous Thromboembolism in Cancer: The Scandinavian Thrombosis and Cancer Cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-06)The risk of venous thromboembolism (VTE) in patients who survive the first years after a cancer diagnosis after the acute effects of disease and treatment in comparison to a similar background population has been sparsely investigated. The aim of the study was to investigate if incidence rates (IRs) of VTE differed in patients who were alive at least 2 years after a cancer diagnosis without VTE ... -
Urinary Markers of Oxidative Stress Are Associated With Albuminuria But Not GFR Decline
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-07)<p><i>Introduction</i>: Markers of oxidative stress increase with age and are prevalent with chronic kidney disease. However, the role of oxidative stress markers as predictors for kidney function decline in the general population is unclear.</p> <p><i>Methods</i>: We investigated whether a baseline urinary excretion of oxidative DNA damage (8-oxo-7,8-dihydro-2′-deoxyguanosine [8-oxodG]) and ... -
Mild Albuminuria Is a Risk Factor for Faster GFR Decline in the Nondiabetic Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-08)<i>Introduction</i>: A minimal increase in the albumin-to-creatinine ratio (ACR) predicts cardiovascular disease and mortality, but whether it predicts kidney function loss in nondiabetic persons is unclear. We investigated the association between ACR in the optimal or high-normal range and the rate of glomerular filtration rate (GFR) decline in a cohort from the general population without diabetes, ... -
Radiation-Induced Transformation of Immunoregulatory Networks in the Tumor Stroma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-26)The implementation of novel cancer immunotherapies in the form of immune checkpoint blockers represents a major advancement in the treatment of cancer, and has renewed enthusiasm for identifying new ways to induce antitumor immune responses in patients. Despite the proven efficacy of neutralizing antibodies that target immune checkpoints in some refractory cancers, many patients do not experience ... -
DC/TMD Examiner Protocol: Longitudinal Evaluation on Interexaminer Reliability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-26)<i>Objectives</i>: The objectives of this study were to assess the interexaminer agreement between one “reference” (gold standard) and each of two examiners, using the DC/TMD examination method, Axis I and to evaluate whether a recalibration changed reliability values. <p> <p><i>Methods</i>: Participants (4 healthy and 12 TMD patients) in 2013 underwent a clinical examination according to ... -
Caesarean section rates and activity-based funding in Northern Norway: A model-based study using the World Health Organization's recommendation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-16)<i>Objective</i>: Caesarean section (CS) rates vary significantly worldwide. ,e World Health Organization (WHO) has recommended a maximum CS rate of 15%. Norwegian hospitals are paid per CS (activity-based funding), employing the diagnosis-related group (DRG) system. We aimed to document how financial incentives can be affected by reduced CS rates, according to the WHO’s recommendation. <p> <p> ... -
Achieving hidradenitis suppurativa response score is associated with significant improvement in clinical and patient-reported outcomes: Post hoc analysis of pooled data from PIONEER I and II
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-07)Hidradenitis Suppurativa Clinical Response (HiSCR), is a validated tool that has been used to assess the efficacy of adalimumab among patients with hidradenitis suppurativa. We evaluated the clinical meaning of HiSCR by relating it to patient-reported outcomes to give further context to its achievement in a post hoc analysis of integrated data from two phase 3 clinical trials (PIONEER I and II). ... -
Comparative exoproteome profiling of an invasive and a commensal Staphylococcus haemolyticus isolate
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-22)<p><i>Staphylococcus haemolyticus</i> is a skin commensal emerging as an opportunistic pathogen. Nosocomial isolates of <i>S. haemolyticus</i> are the most antibiotic resistant members of the coagulase negative staphylococci (CoNS), but information about other <i>S. haemolyticus</i> virulence factors is scarce. Bacterial membrane vesicles (MVs) are one mediator of virulence by enabling secretion and ... -
Life after conflict-related amputation trauma: A clinical study from the Gaza Strip
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-31)<i>Background</i>: More than 17.000 Palestinians were injured during different Israeli military incursions on the Gaza Strip from 2006 to 2014. Many suffered traumatic extremity amputations. We describe the injuries, complications, living conditions and health among a selection of traumatic amputees in the Gaza Strip.<p> <p><i>Methods</i>: We included 254 civilian Palestinians who had survived, ... -
Hypocomplementemia as a Risk Factor for Organ Damage Accrual in Patients with Systemic Lupus Erythematosus
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-30)While it is a common practice to monitor complement levels in patients with systemic lupus erythematosus to aid in flare prediction and detection, it is unclear if this strategy is helpful in preventing subsequent organ damage. We studied longitudinal complement levels in 102 SLE patients during a median follow-up of 13.8 years (IQR 7.0, 23.1). Low complement was defined as C3 < 0.84 g/L and/or ... -
Factors Determining the Success and Failure of eHealth Interventions: Systematic Review of the Literature
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-01)<p><i>Background</i>: eHealth has an enormous potential to improve healthcare cost, effectiveness, and quality of care. However, there seems to be a gap between the foreseen benefits of research and clinical reality.</p> <p><i>Objective</i>: Our objective was to systematically review the factors influencing the outcome of eHealth interventions in terms of success and failure.</p> <p><i>Methods</i>: ... -
Local control and possibility of tailored salvage after hypofractionated stereotactic radiotherapy of the cavity after brain metastases resection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-09)In patients undergoing surgical resection of brain metastases, the risk of local recurrence remains high. Adjuvant whole brain radiation therapy (WBRT) can reduce the risk of local relapse but fails to improve overall survival. At two tertiary care centers in Germany, a retrospective study was performed to evaluate the role of hypofractionated stereotactic radiotherapy (HFSRT) in patients with brain ... -
Benchmarking of aggregated length of stay after open and laparoscopic surgery for cancers of the digestive system
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-23)<i>Background</i>: Length of hospital stay (LOS) may serve as a surrogate measure of healthcare quality and resource use, particularly when transfers of care and readmissions are accounted for. This study aimed to benchmark true hospital stay by measuring index, transfer and readmission stays across the range of digestive cancer surgery.<p> <p><i>Methods</i>: A cohort study of all patients ... -
Culture-negative early-onset neonatal sepsis - at the crossroad between efficient sepsis care and antimicrobial stewardship
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-09)Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of symptoms are suboptimal. Clinical suspicion therefore frequently leads to empirical antibiotic therapy in uninfected infants. The incidence of culture confirmed early-onset sepsis is rather low, around 0.4–0.8/1000 term ... -
Sex differences in umbilical artery Doppler indices: A longitudinal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-18)<p><i>Background</i>: Sexual dimorphism in placental size and function has been described. Whether this influences the clinically important umbilical artery (UA) waveform remains controversial, although a few cross-sectional studies have shown sex differences in UA pulsatility index (PI). Therefore, we tested whether fetal sex influences the UA Doppler indices during the entire second half of pregnancy ... -
Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06)<p><i>Objective</i>: Low serum 25(OH)D levels are associated with cardiovascular disease (CVD) and some of its risk factors. However, in interventional studies, the effects of vitamin D supplementation have been uncertain, possibly due to inclusion of vitamin D-sufficient subjects. Our aim was therefore to examine effects of vitamin D supplementation on CVD risk factors in vitamin D-insufficient ... -
Clinical videoconferencing as ehealth: A critical-realist review and qualitative meta-synthesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-25)<p><i>Background</i>: Earlier work has described videoconferencing technologies, peripheral equipment, organizational models, human relations, purposes, goals and roles as versatile, multifaceted, and those used differently in different clinical practices. Knowledge about benefits and challenges connected to specific characteristics of services are lacking. A 2005 systematic review of published ...