Institutt for klinisk medisin: Recent submissions

Now showing items 521-540 of 1800

    • One-Year Remission Rate of Chronic Headache Comparing Video and Face-to-Face Consultations by Neurologist: Randomized Controlled Trial 

      Bekkelund, Svein Ivar; Müller, Kai Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      Background: Chronic headache causing severe headache-related disability for those affected by the disease is under- or misdiagnosed in many cases and therefore requires easy access to a specialist for optimal health care management.<p> <p>Objective: The goal of the research is to determine whether video consultations are noninferior to face-to-face consultations in treating chronic headache ...

    • Serum miR371 in testicular germ cell cancer before and after orchiectomy, assessed by digital-droplet PCR in a prospective study 

      Myklebust, Mette Pernille; Thor, Anna; Rosenlund, Nina Benedikte; Gjengstø, Peder; Karlsdottir, Åsa; Brydøy, Marianne; Bercea, Bogdan Stefan; Olsen, Christian; Johnson, Ida; Berg, Mathilde I.; Langberg, Carl; Andreassen, Kristine; Kjellman, Anders; Haugnes, Hege Sagstuen; Dahl, Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)
      MicroRNA-371a-3p (miR371) has been suggested as a sensitive biomarker in testicular germ cell cancer (TGCC). We aimed to compare miR371 with the classical biomarkers α-fetoprotein (AFP) and β-human chorionic gonadotropin (hCG<sub>β</sub>). Overall, 180 patients were prospectively enrolled in the study, with serum samples collected before and after orchiectomy. We compared the use of digital droplet ...

    • M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis 

      Brix, Ninna; Glerup, Mia; Thiel, Steffen; Mistegaard, Clara Elbæk; Skals, Regitze Gyldenholm; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan Mary; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Albertsen, Birgitte Klug; Herlin, Troels (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-22)
      Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague. The primary aim was to examine the use of lectin complement pathway proteins as markers to differentiate ALLarthropathy from JIA. The secondary aims were ...

    • MRI in the Assessment of TMJ-Arthritis in Children with JIA; Repeatability of a Newly Devised Scoring System 

      Angenete, Oskar W; Augdal, Thomas Angell; Rygg, Marite; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-19)
      Rationale and Objectives: The temporomandibular joint (TMJ) is commonly involved in children with juvenile idiopathic arthritis. The diagnosis and evaluation of the disease progression is dependent on medical imaging. The precision of this imaging is under debate. SeveralR scoring systems have been proposed but transparent testing of the precision of the constituents of the scoring systems is ...

    • Association of iron deficiency with incident cardiovascular diseases and mortality in the general population 

      Schrage, Benedict; Rübsamen, Nicole; Ojeda, Francisco; Thorand, Barbara; Peters, Annette; Koenig, Wolfgang; Söderberg, Stefan; Söderberg, Maja; Mathiesen, Ellisiv B.; Njølstad, Inger; Kee, Frank; Linneberg, Allan; Kuulasmaa, Kari; Palosaari, Tarja; Salomaa, Veikko; Blankenberg, Stefan; Zeller, Tanja; Karakas, Mahir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-05)
      Aims - Although absolute (AID) and functional iron deficiency (FID) are known risk factors for patients with cardiovascular (CV) disease, their relevance for the general population is unknown. The aim was to assess the association between AID/FID with incident CV disease and mortality in the general population.<p> <p>Methods and results - In 12 164 individuals from three European population-based ...

    • Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets 

      Matsushita, K; Jassal, Simerjot; Solbu, Marit Dahl; Sang, Yingying; Ballew, Shoshana H.; Grams, Morgan E.; Surapaneni, Aditya; Arnlov, Johan; Bansal, Nisha; Bozic, Milica; Brenner, Hermann; Brunskill, Nigel J.; Chang, Alex R.; Chinnadurai, Rajkumar; Cirillo, Massimo; Correa, Adolfo; Ebert, Natalie; Eckardt, Kai-Uwe; Gansevoort, Ron T.; Gutierrez, Orlando; Hadaegh, Farzad; He, Jiang; Hwang, Shih-Jen; Jafar, Tazeen H.; Kayama, Takamasa; Kovesdy, Csaba P.; Landman, Gijs W.; Levey, Andrew S.; Lloyd-Jones, Donald M.; Major, Rupert W.; Miura, Katsuyuki; Muntner, Paul; Nadkarni, Girish N.; Naimark, David M.J.; Nowak, Christoph; Ohkubo, Takayoshi; Pena, Michelle J.; Polkinghorne, Kevan R.; Sabanayagam, Charumathi; Sairenchi, Toshimi; Schneider, Markus P.; Shalev, Varda; Shlipak, Michael; Stempniewicz, Nikita; Tollitt, James; Valdivielso, José M.; van der Leeuw, Joep; Wang, Angela Yee-Moon; Wen, Chi-Pang; Woodward, Mark; Yatsuya, Hiroshi; Zhang, Luxia; Schaeffner, Elke; Coresh, Josef (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-04)
      Background: Chronic kidney disease (CKD) measures (estimated glomerular filtration rate [eGFR] and albuminuria) are frequently assessed in clinical practice and improve the prediction of incident cardiovascular disease (CVD), yet most major clinical guidelines do not have a standardized approach for incorporating these measures into CVD risk prediction. “CKD Patch” is a validated method to calibrate ...

    • Human blood serum proteome changes after 6 hours of sleep deprivation at night 

      Bjørkum, Alvhild Alette; Duran, Ana Carasco; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-25)
      Background: The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories that might be clinically relevant, by exploring systems biological databases.<p> <p>Methods: Eight females were recruited by volunteer request. Peripheral venous whole blood was ...

    • Automated quantitative evaluation of fetal atrioventricular annular plane systolic excursion 

      Herling, L.; Johnson, J.; Ferm-Widlund, K.; Zamprakou, A.; Westgren, M.; Acharya, G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-07)
      Objectives The primary aim of this study was to evaluate the feasibility of automated measurement of fetal atrioventricular (AV) plane displacement (AVPD) over several cardiac cycles using myocardial velocity traces obtained by color tissue Doppler imaging (cTDI). The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, to assess fetal ...

    • Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight 

      Iurilli, Maria Laura Caminia; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino Antonio Moura; Chirita-Emandi, Adela; Hayes, Alison J; Ikeda, Nayu; Jackson, Rod T.; Khang, Young-Ho; Laxmaiah, Avula; Liu, Jing; Miranda, J. Jaime; Saidi, Olfa; Sebert, Sylvain; Sorić, Maroje; Starc, Gregor; Gregg, Edward W.; Abarca-Gómez, Leandra; Abdeen, Ziad A.; Abdrakhmanova, Shynar; Ghaffar, Suhaila Abdul; Rahim, Hanan Abdul; Abu-Rmeileh, Niveen M.; Garba, Jamila Abubakar; Acosta-Cazares, Benjamin; Adams, Robert J.; Aekplakorn, Wichai; Afsana, Kaosar; Afzal, Shoaib; Agdeppa, Imelda A.; Aghazadeh-Attari, Javad; Aguilar-Salinas, Carlos A.; Agyemang, Charles; Ahmad, Mohamad Hasnan; Ahmad, Noor Ani; Ahmadi, Ali; Ahmadi, Naser; Hassan, Soheir; Andersen, Lars Bo; Anderssen, Sigmund Alfred; Ariansen, Inger Kristine Holtermann; Bergh, Ingunn Holden; Bjertness, Espen; Bjertness, Marius Bergsmark; Ekelund, Ulf; Graff-Iversen, Sidsel; Grøholt, Else Karin; Haugsgjerd, Teresa Risan; Janszky, Imre; Kolle, Elin; Krokstad, Steinar; Madar, Ahmed Ali; Mathiesen, Ellisiv B.; Meisfjord, Jørgen Rajan; Meyer, Haakon Eduard; Sen, Abhijit; Skodje, Gry Irene; Sørgjerd, Elin Pettersen; Sparboe-Nilsen, Bente; Steene-Johannessen, Jostein; Tarp, Jakob; Tell, Grethe S.; Torheim, Liv Elin; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-09)
      From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based ...

    • Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood 

      Storm, Benjamin; Christiansen, Dorte; Fure, Hilde; Ludviksen, Judith K; Lau, Corinna; Lambris, John D.; Woodruff, Trent M.; Brekke, Ole-Lars; Braaten, Tonje Bjørndal; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)
      Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on complement and its role in thromboinflammation. Whole blood from 16 donors was incubated with air bubbles without or with inhibitors of C3, C5, C5aR1, or CD14. Complement activation, ...

    • Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis 

      Dorraji, Seyed Esmaeil; Oteiza, Ana; Kuttner, Samuel; Martin, Armas Maria Montserrat; Kanapathippillai, Premasany; Garbarino, Sara; Kalda, Gustav; Scussolini, Mara; Piana, Michele; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
      Lymphoid neogenesis occurs in tissues targeted by chronic inflammatory processes, such as infection and autoimmunity. In systemic lupus erythematosus (SLE), such structures develop within the kidneys of lupus-prone mice ((NZBXNZW)F1) and are observed in kidney biopsies taken from SLE patients with lupus nephritis (LN). The purpose of this prospective longitudinal animal study was to detect early ...

    • Plasma levels of leptin and risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-11)
      Background - Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain.<p> <p>Objective - This article investigates the association between ...

    • Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway 

      Kjønås, Didrik; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Røsner, Assami; Dahle, Gry (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-06)
      Objectives: Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity of our own previously developed model in a separate and more recent cohort.<p> <p>Methods: The ...

    • Serum Matrix Metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population 

      Enoksen, Inger Therese T.; Svistounov, Dmitri; Norvik, Jon Viljar; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Eriksen, Bjørn Odvar; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)
      Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with ...

    • Associations between cervical dilatation on admission and mode of delivery, a cohort study of Norwegian nulliparous women 

      Gjærum, Ragnhild; Johansen, Ingvild; Øian, Pål; Bernitz, Stine; Dalbye, Rebecka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Objective - To investigate associations between cervical dilatation at hospital admission and mode of delivery.<p> <p>Methods - A cohort study with data from a cluster-randomised controlled trial, the Labour Progression Study. The study population of 6511 nulliparous women with a singleton fetus in cephalic presentation with spontaneous onset of labour at term, was divided into two groups: <4 cm ...

    • A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT 

      Jørgensen, Silje Fjellgård; Buechner, Jochen; Myhre, Anders E.; Galteland, Eivind; Spetalen, Signe; Kulseth, Mari Ann; Sorte, Hanne Sørmo; Holla, Øystein Lunde; Lundman, Emma; Alme, Charlotte; Heier, Ingvild; Flægstad, Trond; Fløisand, Yngvar; Benneche, Andreas; Fevang, Børre; Aukrust, Pål; Stray-Pedersen, Asbjørn; Gedde-Dahl, Tobias; Nordøy, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)
      Purpose: GATA2 deficiency is a rare primary immunodeficiency that has become increasingly recognized due to improved molecular diagnostics and clinical awareness. The only cure for GATA2 deficiency is allogeneic hematopoietic stem cell transplantation (allo-HSCT). The inconsistency of genotype-phenotype correlations makes the decision regarding "who and when" to transplant challenging. Despite ...

    • Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial 

      Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Tidsskriftartikkel, 2021-09-20)
      Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...

    • Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors 

      Butler, Lynn; Iglesias, Maria J.; Kruse, Larissa D.; Sanchez-Rivera, Laura; Enge, Linnea; Dusart, Philip; Hong, Mun-Gwan; Uhlén, Mathias; Renné, Thomas; Schwenk, Jochen M.; Bergstrom, Göran; Odeberg, Jacob (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
      <b>Objective:</b> Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor ...

    • Development of quantitative assay for simultaneous measurement of purine metabolites and creatinine in biobanked urine by liquid chromatography-tandem mass spectrometry 

      Svistounov, Dmitri; Solbu, Marit Dahl; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Hansen, Terkel; Elgstøen, Katja Benedikte Prestø; Zykova, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)
      Purine metabolism is essential for all known living creatures, including humans in whom elevated serum concentration of purine break-down product uric acid (UA) is probably an independent risk factor for mortality, type 2 diabetes and cardiovascular events. An automated multiplex assay that measures several purine metabolites could therefore prove useful in many areas of medical, veterinary and ...

    • Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy: Results of a Randomized Clinical Trial 

      Al-Ani, Zeiad; Meknas, Dana; Kartus, Jüri-Tomas; Lyngedal, Øyvind; Meknas, Khaled (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
      Background: Achilles tendinopathy is a painful disorder, and various treatment options are available. Bipolar radiofrequency microtenotomy (RFM) has shown promising results in treating tendinosis.<p> <p>Purpose/Hypothesis: The purpose was to compare the results between treatment with bipolar RFM and physical therapy (PT) for patients with midportion Achilles tendinopathy. It was hypothesized that ...