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norskInstitutt for klinisk medisin: Recent submissions
Now showing items 761-780 of 1800
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Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-15)Growth differentiation factor 15 (GDF-15), a marker of inflammation and oxidative stress, has emerged as a biomarker for arterial cardiovascular disease. However, the association between GDF-15 and venous thromboembolism (VTE) remains uncertain. We therefore investigated the association between plasma GDF-15 levels and future risk of incident VTE and explored the potential of a causal association ... -
Criteria for success after surgery for cervical radiculopathy—estimates for a substantial amount of improvement in core outcome measures
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-02)<i>Background context</i> - Defining clinically meaningful success criteria from patient-reported outcome measures (PROMs) is crucial for clinical audits, research and decision-making.<p> <p><i>Purpose</i> - We aimed to define criteria for a successful outcome 3 and 12 months after surgery for cervical degenerative radiculopathy on recommended PROMs.<p> <p><i>Study design</i> - Prospective ... -
Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes: A Longitudinal Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)<i>Background</i>: With recent changes in legislation regulating recreational and medical cannabis use around the globe, increased use in pregnancy is to be expected.<p> <p><i>Objectives</i>: To investigate the association between cannabis use during pregnancy and birth outcomes. <p> <p><i>Method</i>: Data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective pregnancy cohort, ... -
The impact of gender, puberty, and pregnancy in patients with POLG disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-18)<i>Objective</i> - To study the impact of gender, puberty, and pregnancy on the expression of POLG disease, one of the most common mitochondrial diseases known.<p> <p><i>Methods</i> - Clinical, laboratory, and genetic data were collected retrospectively from 155 patients with genetically confirmed POLG disease recruited from seven European countries. We used the available data to study the impact ... -
Mental health and health related quality of life in mitochondrial POLG disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R)and Short-Form 36 HealthSurvey (RAND-36). Wefound increased scores in all nine subscales of SCL-90-R, particularly phobic anxiety, depression and somatization. Further, patients reported considerably lower scores in all RAND-36 domains. This study revealed a ... -
Novel bio-compatible tracers for Positron Emission Particle Tracking
(Conference object; Konferansebidrag, 2020-09)To study the flow of objects (tracers) in opaque flow processes, the PEPT (positron emission particle tracking) technique is utilized. The PEPT technique is based on the same principle of PET (positron emission tomography) which detects the characteristic back-to-back gamma pairs caused by positron-electron annihilation. The annihilation takes place within a few millimeters around the tracers labeled ... -
Efficacy and Safety of CT-P13 in Inflammatory Bowel Disease after Switching from Originator Infliximab: Exploratory Analyses from the NOR-SWITCH Main and Extension Trials
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)<i>Background</i> - The NOR-SWITCH main and extension trials demonstrated that switching from originator to biosimilar infliximab (CT-P13) is efficacious and safe across six diseases. However, a subgroup analysis of Crohn’s disease (CD) in the main trial displayed a close to significant difference favouring originator infliximab, and more scientific data have therefore been requested.<p><p> <i> ... -
Behandling av håndleddsbrudd (distale radiusfrakturer) hos voksne
(Research report; Forskningsrapport, 2013-02)I Norge er håndleddsbrudd (distale radiusfrakturer) den vanligste bruddtypen, med en forekomst på ca. 15000 per år. Ved brudd med ingen eller lite feilstilling er det vanlig å behandle med gips. Ved brudd med feilstilling er det aktuelt med mer avanserte teknikker. Det er imidlertid uklart hvilke pasienter som bør opereres og hvem som bør få annen behandling, samt hvilke operasjons-metoder som har ... -
Svake høyfrekvente elektromagnetiske felt - en vurdering av helserisiko og forvaltningspraksis
(Research report; Forskningsrapport, 2012-08)Bruk av utstyr som sender ut radiobølger har økt i senere år. Trådløs kommunikasjonsteknologi som mobiltelefoni dominerer. De siste årene har krav om stadig bedre dekning, teknologi i nye generasjoner og utvidede funksjoner på de mobile tjenestene ført til en betydelig økning av antallet og tettheten av radiosendere. Eksponering for elektromagnetiske felt (EMF) og mulige helseeffekter er sterkt ... -
Description of health-related rehabilitation service provision and delivery in randomized controlled trials: A topic review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-18)Objective: To determine how health-related rehabilitation services have been described in recently pub-lished randomized clinical trials, using the International Classification System for Service Organization in Health-Related Rehabilitation (ICSO-R 2.0) as a framework.<p><p> Methods: Medline was searched for English--language randomized clinical trials (RCTs) published between 1 January 2018 and ... -
Spatial distribution of malignant transformation in patients with low-grade glioma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-09)<i>Background</i> - Malignant transformation represents the natural evolution of diffuse low-grade gliomas (LGG). This is a catastrophic event, causing neurocognitive symptoms, intensified treatment and premature death. However, little is known concerning the spatial distribution of malignant transformation in patients with LGG.<p><p> <i>Materials and methods</i> - Patients histopathological ... -
Individual Variation in Adaptive Immune Responses and Risk of Hip Fracture-A NOREPOS Population-Based Cohort Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)Immune‐mediated bone loss significantly impacts fracture risk in patients with autoimmune disease, but to what extent individual variations in immune responses affect fracture risk on a population level is unknown. To examine how immune responses relate to risk of hip fracture, we looked at the individual variation in a post‐vaccination skin test response that involves some of the immune pathways ... -
Cabin temperature during prehospital patient transport – a prospective observational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-13)<i>Background</i> - Few studies have investigated the patient compartment temperatures during ambulance missions or its relation to admission hypothermia. Still hypothermia is a known risk factor for increased mortality and morbidity in both trauma and disease. This has special relevance to our sub-arctic region’s pre-hospital services, and we prospectively studied the environmental temperature in ... -
Ny medikamentell behandling av brystkreft Adjuvant behandling med trastuzumab ved tidlig stadium av brystkreft - en helseøkonomisk analyse
(Research report; Forskningsrapport, 2006)Denne rapporten er andre del av et oppdrag fra Sosial- og helsedirektoratet og RHF - fagdirektørene med fokus på virkestoffet trastuzumab ved adjuvant behandling av brystkreft. Adjuvant behandling gis i tillegg til hovedbehandlingen (for eksempel kirurgi) for å påvirke eventuelt gjenværende kreftceller hos pasienten. Denne delen av oppdraget vurderer de helseøkonomiske konsekvensene av adjuvant ... -
Ny medikamentell behandling av brystkreft - Adjuvant behandling med trastuzumab ved tidlig stadium av brystkreft
(Research report; Forskningsrapport, 2006)Denne rapporten er første del av et oppdrag fra Sosial- og helsedirektoratet og RHF - fagdirektørene med fokus på effekt og bivirkninger av virkestoffet trastuzumab ved adjuvant behandling av brystkreft. Trastuzumab er ofte omtalt ved produktnavnet Herceptin. -
Helseøkonomisk evaluering av bevacizumab ved metastatisk kolorektalcancer
(Research report; Forskningsrapport, 2007)Vi har gjennomført en modellbasert analyse av kostnadseffektiviteten av bevacizumab som førstelinjebehandling av metastatisk kolorektalcancer (tykk- og endetarmskreft) i Norge. Vi har undersøkt effekten av å legge bevacizumab til standard kjemoterapi. Beregningene er forbundet med betydelig usikkerhet, og resultatene bør derfor tolkes med forsiktighet. -
Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - Secondary analyses of a randomised, placebo-controlled trial (the AIM study)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-13)<i>Background</i> - Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real treatment effect in subgroups of the study populations. The purpose of the present study was to explore potential clinical effect modifiers of 3-months oral amoxicillin ... -
Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)<i>Aims</i> - Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.<p> <p><i>Methods and results</i> - An individual participant meta-analysis was used to associate the annualised progression of systolic ... -
Children's fear of needle injections: A qualitative study of training sessions for children with rheumatic diseases before home administration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-07)<i>Background</i>: Treatment of rheumatic diseases in children often includes long-term needle injections, which represent a risk for refusing medication based on potential needle-fear. How nurses manage children’s fear and pain during the initial educational training session of subcutaneous injections, may affect the management of the subsequent injections in the home settings. The aim of this study ... -
Diagnostic imaging and ionizing radiation exposure in a level 1 trauma centre population met with trauma team activation: a one-year patient record audit
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-15)This audit describes ionizing and non-ionizing diagnostic imaging at a regional trauma centre. All 144 patients (males 79.2%, median age 31 years) met with trauma team activation from 1 January 2015 to 31 December 2015 were included. We used data from electronic health records to identify all diagnostic imaging and report radiation exposure as dose area product (DAP) for conventional radiography ...
