Institutt for klinisk medisin: Nye registreringer

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    • High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism 

      Damoah, Christabel Esi; Snir, Omri; Hindberg, Kristian Dalsbø; Garred, Peter; Ludviksen, Judith K; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)
      Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects against thrombosis. In this study, we investigated whether plasma MASP-2 levels were associated with risk of future venous thromboembolism (VTE) and whether genetic variants linked to ...

    • Observer agreement of imaging measurements used for evaluation of dentofacial deformity in juvenile idiopathic arthritis 

      Fischer, Johannes Maria; Halbig, Josefine Mareile; Augdal, Thomas Angell; Angenete, Oskar W; Stoustrup, Peter; Kristensen, Kasper Dahl; Skeie, Marit Slåttelid; Tylleskär, Karin; Rosén, Annika; Shi, Xie-Qi; Rosendahl, Karen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-02)
      Objectives: To examine the precision of imaging measures commonly used to assess mandibular morphology in children and adolescents with juvenile idiopathic arthritis (JIA). Secondly, to compare cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in the measurement of condylar height.<p> <p>Methods: Those included were children diagnosed with JIA during 2015–18 who had had ...

    • Inflammation and cognition in severe mental illness: patterns of covariation and subgroups 

      Sæther, Linn Sofie; Ueland, Thor; Haatveit, Beathe; Maglanoc, Luigi; Szabo, Attila; Djurovic, Srdjan; Aukrust, Pål; Roelfs, Daniël; Ormerod, Monica Bettina E. Greenwood; Lagerberg, Trine Vik; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole; Ueland, Torill; Mohn, Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)
      A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual ...

    • Bronkiolitt skal ikke behandles med glukokortikoider eller antibiotika 

      Nordal, Ellen Berit; Granslo, Hildegunn Norbakken; Esaiassen, Eirin; Leknessund, Carina Benedikte Bjørkvoll; Forsdahl, Bård Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-30)
      Vi er inne i en hektisk sesong med virale luftveisinfeksjoner. Respiratorisk syncytialvirus (RS-virus) er den hyppigste årsaken til bronkiolitt hos barn. Pediatriveilederen er tydelig på at perorale glukokortikoider ikke har noen plass i behandlingen av bronkiolitt og at det sjelden er behov for antibiotika.

    • Return to Work after Surgery for Cervical Radiculopathy: A Nationwide Registry-based Observational Study 

      Hara, Sozaburo; Lønne, Vetle Vangen; Aasdahl, Lene; Salvesen, Øyvind Olav; Solberg, Tore; Gulati, Sasha; Hara, Karen Walseth (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)
      Study Design - An observational multicenter study.<p> <p>Summary of Background Data - Return to work (RTW) is increasingly used to assess the standard, benefit, and quality of health care.<p> <p>Objective - The aim of this study was to evaluate sick leave patterns among patients undergoing surgery for cervical radiculopathy and identify predictors of successful RTW using two nationwide ...

    • Reflections on the nature of measurement in language-based automated assessments of patients' mental state and cognitive function 

      Foltz, Peter W.; Chandler, Chelsea; Diaz-Asper, Catherine; Cohen, Alex S.; Rodriguez, Zachary; Holmlund, Terje Bektesevic; Elvevåg, Brita (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)
      Modern advances in computational language processing methods have enabled new approaches to the measurement of mental processes. However, the field has primarily focused on model accuracy in predicting performance on a task or a diagnostic category. Instead the field should be more focused on determining which computational analyses align best with the targeted neurocognitive/psychological functions ...

    • Health characteristics associated with chemsex among men who have sex with men: Results from a cross-sectional clinic survey in Norway 

      Amundsen, Eirik; Haugstvedt, Åse; Skogen, Vegard; Berg, Rigmor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)
      Background Chemsex typically involves drugs such as GHB/GBL, crystal meth and mephedrone, and is increasingly common among MSM. The behaviour has been found to be associated with sexually transmitted infections (STIs) and mental health problems. We aimed to assess the extent of chemsex engagement and associations with different aspects of health, among MSM attending a free specialist walk-in clinic ...

    • The use of light, restrictive feeding, fibrous feed and stocking density and the consequences for animal welfare for poultry species kept in Norway - Scientific Opinion of the Panel on Animal Health and Welfare of the Norwegian Scientific Committee for Food and Environment 

      Bøe, Knut Egil; Grahek-Ogden, Danica; Hoel, Kristian; Gjøen, Tor; Godfroid, Jacques Xavier Leon; Janczak, Andrew Michael; Madslien, Knut; Olsen, Rolf-Erik; Rimstad, Espen; Øverli, Øyvind; Agdestein, Angelika (Research report; Forskningsrapport, 2022-06-15)

    • Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study 

      Sejrup, Joakim Knutsen; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-19)
      Background: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated.<p> <p>Aim: To study the joint effect of MI and obesity on the risk of VTE. <p>Methods: Study participants (n = 29 410) were recruited from ...

    • The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension 

      Jørgensen, Helle; Horvath-Puho, Erzsebet; Laugesen, Kristina; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Sørensen, Henrik Toft (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      <p><b> Background: </b>Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension. <p><b> Methods:</b> Using Danish ...

    • Do Sexually Abstinent Women have more pelvic floor Disorders?A cross sectional, population based study 

      Volløyhaug, Ingrid; Lonnée-Hoffmann, Risa Anna Margaretha; Salvesen, Kjell Åsmund Blix; Guzman-Rojas, Rodrigo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-22)
      Introduction and hypothesis: The aims were to establish the prevalence of sexually abstinent women because of Pelvic Floor Disorders (PFDs) in parous women, and to examine if abstinence was associated with symptoms of PFDs or functional anatomy of the pelvic floor. Methods: Cross-sectional study of parous women responding to a questionnaire and undergoing pelvic floor examination. Distress for ...

    • Shortened Palliative Radiotherapy Results in a Lower Rate of Treatment During the Last Month of Life 

      Nieder, Carsten; Haukland, Ellinor Christin; Mannsåker, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)
      Introduction Palliative radiotherapy (PRT) during the last month of life (PRT30) should be avoided because relevant clinical benefits are unlikely to occur. While traditional short-course fractionation regimens are suitable for most patients, a minority may derive gains from higher doses of PRT. Compared to older regimens such as 13 fractions of 3 Gy, more hypofractionated, non-ablative concepts ...

    • Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases 

      Seim, Bjørn Edvard; Holt, Margrethe Flesvig; Ratajska, Aleksandra; Michelsen, Annika Elisabet; Ringseth, Monica Myklebust; Halvorsen, Bente; Skjelland, Mona; Kvitting, John-Peder; Lundblad, Runar; Krohg-Sørensen, Kirsten; Osnes, Liv T. N.; Aukrust, Pål; Paus, Benedicte; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-20)
      Background: In approximately 20% of patients with thoracic aortic aneurysms or dissections a heritable thoracic aortic disease (HTAD) is suspected. Several monogenic connective tissue diseases imply high risk of aortic disease, including both non-syndromic and syndromic forms. There are some studies assessing inflammation and extracellular matrix remodeling in patients with non-hereditary aortic ...

    • Surgery for degenerative cervical myelopathy in patients with rheumatoid arthritis and ankylosing spondylitis: a nationwide registry-based study with patient-reported outcomes 

      Holmberg, Siril Therese; Gulati, Agnete Malm; Johansen, Tonje Okkenhaug; Salvesen, Øyvind; Vangen-Lønne, Vetle; Solberg, Tore; Tronvik, Erling Andreas; Nygaard, Øystein Petter; Gulati, Sasha (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-15)
      Purpose To compare patient-reported outcomes (PROMs) following surgery for degenerative cervical myelopathy (DCM) among patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) versus those without rheumatic diseases. Methods Data were obtained from the Norwegian Registry for Spine Surgery. The primary outcome was change in the Neck Disability Index (NDI) at 1 year. Secondary endpoints ...

    • Reproductive changes among women in their 40s: A cross-sectional study 

      Lindh, Ingela; Skjeldestad, Finn Egil; Heikinheimo, Oskari; Hognert, Helena; Lidegaard, Øjvind; Bergh, Christina; Gemzell-Danielsson, Kristina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-05)
      Introduction The aim was to describe and compare changes in the reproductive pattern of women in their 40s observed over a decade in Scandinavia. Material and Methods Cross-sectional study using the total population of women aged 40–49 years between 2008–2018 in Denmark, Norway and Sweden (on average n = 1.5 million). Aggregated data concerning birth and induced abortion rate were collected and ...

    • The impact of implementing patient-reported measures in routine maternity care: a systematic review 

      Chen, An; Väyrynen, Kirsi; Schmidt, Alexandra; Leskelä, Riikka-Leena; Torkki, Paulus; Heinonen, Seppo; Tekay, Aydin; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)
      Introduction While there is growing interest in applying patient-reported measures (PRMs) in clinical routine, limited collective evidence of the impact of PRMs hinder their widespread use in specific contexts, such as maternity care. Our objective was to synthesize existing emperical evidence on the impact of implementing PRMs in routine maternity care. Material and methods We followed the ...

    • External Validation of the Graded Prognostic Assessment in Patients with Brain Metastases from Small Cell Lung Cancer 

      Nieder, Carsten; Popp, Ilinca; Hintz, Mandy; Grosu, Anca Ligia (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-29)
      Background: Recently, graded prognostic assessment (GPA) for small cell lung cancer (SCLC) patients with brain metastases has been developed. This includes age, performance status, number of brain metastases and presence of extracranial metastases. The aim of the present study was to validate this four-tiered prognostic score in a European cohort of patients. Methods: The retrospective validation ...

    • Epidemiology and natural history in 101 subjects with FKRP-related limb-girdle muscular dystrophy R9. The Norwegian LGMDR9 cohort study (2020) 

      Jensen, Synnøve; Müller, Kai Ivar; Mellgren, Svein Ivar; Bindoff, Laurence Albert; Rasmussen, Magnhild; Ørstavik, Kristin; Jonsrud, Christoffer; Tveten, Kristian; Nilssen, Øivind; Van Ghelue, Marijke; Arntzen, Kjell Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)
      We aimed to investigate the epidemiology and natural history of FKRP-related limb-girdle muscular dystrophy R9 (LGMDR9) in Norway. We identified 153 genetically confirmed subjects making the overall prevalence 2.84/100,000, the highest reported figure worldwide. Of the 153 subjects, 134 (88 %) were homozygous for FKRP c.826C>A giving a carrier frequency for this variant of 1/101 in Norway. Clinical ...

    • Magnetic resonance imaging for non-invasive measurement of plastic ingestion in marine wildlife 

      Anderssen, Kathryn Elizabeth; Gabrielsen, Geir W.; Kranz, Mathias; Collard, France (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)
      Monitoring plastic ingestion by marine wildlife is important for both characterizing the extent of plastic pollution in the environment and understanding its effect on species and ecosystems. Current methods to detect plastic in the digestive system of animals are slow and invasive, such that the number of animals that can be screened is limited. In this article, magnetic resonance imaging (MRI) ...

    • Symptoms of Depression, Anxiety, and Posttraumatic Stress among Patients with Cardiac Pacemakers 

      Bürker, Britta Susanne; Halvorsen, Randolf Inge; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-15)
      Despite being a prerequisite for tailoring specific therapeutic interventions, knowledge of pattern and prevalence of clinically significant psychiatric symptomatology among patients with cardiac pacemakers (PMs), especially of symptoms of posttraumatic stress, is limited. We studied symptoms of depression, anxiety, and posttraumatic stress among PM patients (PM due to syncope or presyncope) ...